About the Authors

Akira Nakatsuma

Affiliation Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Japan

Mugiho Kaneda

Affiliation Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Japan

Hiromi Kodama

Affiliation Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Japan

Mika Morikawa

Affiliations Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Japan, TAUNS Laboratories, Inc., Izunokuni, Japan

Satoshi Watabe

Affiliation BL Co., Ltd., Numazu, Japan

Kazunari Nakaishi

Affiliation TAUNS Laboratories, Inc., Izunokuni, Japan

Masakane Yamashita

Affiliation Faculty of Science, Hokkaido University, Sapporo, Japan

Teruki Yoshimura

Affiliation Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan

Toshiaki Miura

Affiliation Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan

Masaki Ninomiya

Affiliation Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Japan

Etsuro Ito

eito@kph.bunri-u.ac.jp

Affiliation Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Japan

Competing Interests

MM and KN are employees of TAUNS Laboratories, Inc., and SW is an employee of BL Co., Ltd. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SW EI. Performed the experiments: AN MK HK MM TY. Analyzed the data: AN MK EI. Wrote the paper: AN MK SW KN MY TY TM MN EI.