About the Authors

Andrew T. Miller

amiller@gnf.org

Affiliation The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America

Carol Dahlberg

Affiliation The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America

Mark L. Sandberg

Affiliation The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America

Ben G. Wen

Affiliation The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America

Daniel R. Beisner

Affiliation The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America

John A. H. Hoerter

Affiliation The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America

Albert Parker

Affiliation The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America

Christian Schmedt

Affiliation The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America

Monique Stinson

Affiliation The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America

Jacqueline Avis

Affiliation The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America

Cynthia Cienfuegos

Affiliation The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America

Mark McPate

Affiliation Novartis Pharmaceuticals UK Limited, Respiratory Disease Area, Horsham, West Sussex, United Kingdom

Pamela Tranter

Affiliation Novartis Pharmaceuticals UK Limited, Respiratory Disease Area, Horsham, West Sussex, United Kingdom

Martin Gosling

Affiliation Novartis Pharmaceuticals UK Limited, Respiratory Disease Area, Horsham, West Sussex, United Kingdom

Paul J. Groot-Kormelink

Affiliation Novartis Institutes for Biomedical Research, Musculoskeletal Disease Area, Basel, Switzerland

Janet Dawson

Affiliation Novartis Pharma AG, Novartis Institutes for Biomed. Research, Basel, Switzerland

Shifeng Pan

Affiliation The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America

Shin-Shay Tian

Affiliation The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America

H. Martin Seidel

Affiliation The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America

Michael P. Cooke

Affiliation The Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California, United States of America

Competing Interests

All work was funded by the Novartis Institutes for Biomedical Research. All authors are employed by either Novartis Research Foundation (GNF), Novartis Pharmaceuticals UK Limited, Novartis Institutes for Biomedical Research and Novartis Pharma AG. There are no products in development or marketed products to declare. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ATM MLS BGW DRB PT PJGK JD MPC. Performed the experiments: CD MLS DRB JAH AP CS MS MM JA CC. Analyzed the data: ATM CD MLS BGW DRB JAH AP CS MS MM PT MG PJGK JD SP SST HMS MPC. Wrote the paper: ATM MPC.