Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells

Pei-Shan Wu; Jui-Hung Yen; Mei-Chun Kou; Ming-Jiuan Wu

doi:10.1371/journal.pone.0130599

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Peer-reviewed

Research Article

Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells

Pei-Shan Wu,

Affiliation Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, 717, Taiwan
⨯
Jui-Hung Yen,

Affiliation Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, 970, Taiwan
⨯
Mei-Chun Kou,

Affiliation Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, 717, Taiwan
⨯
Ming-Jiuan Wu

* E-mail: imwu@mail.cnu.edu.tw

Affiliation Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, 717, Taiwan
⨯

Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells

Pei-Shan Wu,
Jui-Hung Yen,
Mei-Chun Kou,
Ming-Jiuan Wu

Published: June 18, 2015
https://doi.org/10.1371/journal.pone.0130599

About the Authors

Pei-Shan Wu

Affiliation Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, 717, Taiwan

Jui-Hung Yen

Affiliation Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, 970, Taiwan

Mei-Chun Kou

Affiliation Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, 717, Taiwan

Ming-Jiuan Wu

* E-mail: imwu@mail.cnu.edu.tw

Affiliation Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, 717, Taiwan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JHY MJW. Performed the experiments: PSW MCK. Analyzed the data: PSW MJW. Contributed reagents/materials/analysis tools: JHY MJW. Wrote the paper: JHY MJW.

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MAPK signaling cascades
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Endoplasmic reticulum
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Cytotoxicity
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Apoptosis
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Gene expression
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Stress signaling cascade
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Autophagic cell death
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Cellular stress responses
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