About the Authors

Masaki Watabe

Affiliation Laboratory for Biochemical Simulation, Quantitative Biology Center, RIKEN, Suita, Osaka, Japan

Satya N. V. Arjunan

Affiliation Laboratory for Biochemical Simulation, Quantitative Biology Center, RIKEN, Suita, Osaka, Japan

Seiya Fukushima

Affiliations Laboratory for Cell Signaling Dynamics, Quantitative Biology Center, RIKEN, Suita, Osaka, Japan, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan

Kazunari Iwamoto

Affiliation Laboratory for Biochemical Simulation, Quantitative Biology Center, RIKEN, Suita, Osaka, Japan

Jun Kozuka

Affiliation Laboratory for Cell Signaling Dynamics, Quantitative Biology Center, RIKEN, Suita, Osaka, Japan

Satomi Matsuoka

Affiliation Laboratory for Cell Signaling Dynamics, Quantitative Biology Center, RIKEN, Suita, Osaka, Japan

Yuki Shindo

Affiliations Laboratory for Biochemical Simulation, Quantitative Biology Center, RIKEN, Suita, Osaka, Japan, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan

Masahiro Ueda

Affiliations Laboratory for Cell Signaling Dynamics, Quantitative Biology Center, RIKEN, Suita, Osaka, Japan, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan

Koichi Takahashi

ktakahashi@riken.jp

Affiliations Laboratory for Biochemical Simulation, Quantitative Biology Center, RIKEN, Suita, Osaka, Japan, Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Performed the experiments: SF SM YS. Wrote the paper: MW. Conceived and designed the computational framework: MW KT. Wrote the software: MW. Constructed cell models: MW SNVA KI. Provided support and guidance: JK MU KT.