About the Authors

Giulia Maria Camerino

Affiliation Section of Pharmacology, Dept. of Pharmacy & Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy

Jean-François Desaphy

Affiliation Section of Pharmacology, Dept. of Pharmacy & Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy

Michela De Bellis

Affiliation Section of Pharmacology, Dept. of Pharmacy & Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy

Roberta Francesca Capogrosso

Affiliation Section of Pharmacology, Dept. of Pharmacy & Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy

Anna Cozzoli

Affiliation Section of Pharmacology, Dept. of Pharmacy & Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy

Maria Maddalena Dinardo

Affiliation Section of Pharmacology, Dept. of Pharmacy & Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy

Roberta Caloiero

Affiliation Section of Pharmacology, Dept. of Pharmacy & Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy

Kejla Musaraj

Affiliation Section of Pharmacology, Dept. of Pharmacy & Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy

Adriano Fonzino

Affiliation Section of Pharmacology, Dept. of Pharmacy & Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy

Elena Conte

Affiliation Section of Pharmacology, Dept. of Pharmacy & Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy

Catherine Jagerschmidt

Affiliation Galapagos-SASU, Romainville, France

Florence Namour

Affiliation Galapagos-SASU, Romainville, France

Antonella Liantonio

Affiliation Section of Pharmacology, Dept. of Pharmacy & Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy

Annamaria De Luca

Affiliation Section of Pharmacology, Dept. of Pharmacy & Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy

Diana Conte Camerino

Affiliation Section of Pharmacology, Dept. of Pharmacy & Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy

Sabata Pierno

sabata.pierno@uniba.it

Affiliation Section of Pharmacology, Dept. of Pharmacy & Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy

Competing Interests

CJ and FN are employed by Galapagos, which contributed to financial support. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The other authors have declared that no competing interests exist. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: GMC JFD DCC SP. Performed the experiments: GMC MDB RFC AC MMD RC KM AF EC AL SP. Analyzed the data: GMC JFD MDB RC KM AF EC AL ADL DCC SP. Contributed reagents/materials/analysis tools: DCC CJ FN. Wrote the paper: GMC JFD DCC SP. Critically read the manuscript: CJ FN ADL.