Mitochondrial Ultrastructural Alterations and Declined M2 Receptor Density Were Involved in Cardiac Dysfunction in Rats after Long Term Treatment with Autoantibodies against M2 Muscarinic Receptor

Suli Zhang; Zhongmei He; Jin Wang; Li Wang; Ye Wu; Jie Wang; Tingting Lv; Huirong Liu

doi:10.1371/journal.pone.0129563

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Peer-reviewed

Research Article

Mitochondrial Ultrastructural Alterations and Declined M₂ Receptor Density Were Involved in Cardiac Dysfunction in Rats after Long Term Treatment with Autoantibodies against M₂ Muscarinic Receptor

Suli Zhang ,

Contributed equally to this work with: Suli Zhang, Zhongmei He

Affiliations Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, P. R. China, The Key Laboratory of Remodeling-related Cardiovascular Diseases, Capital Medical University, Ministry of Education, Beijing, 100069, P. R. China
⨯
Zhongmei He ,

Contributed equally to this work with: Suli Zhang, Zhongmei He

Affiliation Department of Physiology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China
⨯
Jin Wang,

Affiliation Department of Physiology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China
⨯
Li Wang,

Affiliation Department of Pathology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China
⨯
Ye Wu,

Affiliations Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, P. R. China, The Key Laboratory of Remodeling-related Cardiovascular Diseases, Capital Medical University, Ministry of Education, Beijing, 100069, P. R. China
⨯
Jie Wang,

Affiliation Department of Neurology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China
⨯
Tingting Lv,

Affiliation Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, P. R. China
⨯
Huirong Liu

* E-mail: liuhr2000@126.com

Affiliations Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, P. R. China, Department of Physiology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China, Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, Capital Medical University, Beijing, 100069, P. R. China
⨯

Mitochondrial Ultrastructural Alterations and Declined M₂ Receptor Density Were Involved in Cardiac Dysfunction in Rats after Long Term Treatment with Autoantibodies against M₂ Muscarinic Receptor

Suli Zhang,
Zhongmei He,
Jin Wang,
Li Wang,
Ye Wu,
Jie Wang,
Tingting Lv,
Huirong Liu

Published: June 18, 2015
https://doi.org/10.1371/journal.pone.0129563

About the Authors

Suli Zhang

Contributed equally to this work with: Suli Zhang, Zhongmei He

Affiliations Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, P. R. China, The Key Laboratory of Remodeling-related Cardiovascular Diseases, Capital Medical University, Ministry of Education, Beijing, 100069, P. R. China

Zhongmei He

Contributed equally to this work with: Suli Zhang, Zhongmei He

Affiliation Department of Physiology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China

Jin Wang

Affiliation Department of Physiology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China

Li Wang

Affiliation Department of Pathology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China

Ye Wu

Jie Wang

Affiliation Department of Neurology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China

Tingting Lv

Affiliation Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, P. R. China

Huirong Liu

* E-mail: liuhr2000@126.com

Affiliations Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, P. R. China, Department of Physiology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China, Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, Capital Medical University, Beijing, 100069, P. R. China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HL. Performed the experiments: SZ ZH Jin Wang LW YW TL. Analyzed the data: Jin Wang Jie Wang. Wrote the paper: SZ ZH Jin Wang LW YW TL HL.

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Mitochondria
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Cardiovascular physiology
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Heart
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Systolic pressure
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Autoantibodies
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Cardiac ventricles
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Immune receptors
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Mitochondrial membrane
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