About the Authors

Hidetoshi Kumagai

Contributed equally to this work with: Hidetoshi Kumagai, Yuichi Ikeda, Yoshihiro Motozawa

hdtshkmg@gmail.com

Affiliations Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Tokyo, Japan

Yuichi Ikeda

Contributed equally to this work with: Hidetoshi Kumagai, Yuichi Ikeda, Yoshihiro Motozawa

Affiliations Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Yoshihiro Motozawa

Contributed equally to this work with: Hidetoshi Kumagai, Yuichi Ikeda, Yoshihiro Motozawa

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Mitsuhiro Fujishiro

Affiliation Department of Gastroenterology, Graduate Scholl of Medicine, The University of Tokyo, Tokyo, Japan

Tomohisa Okamura

Affiliations Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Max Plank- The University of Tokyo Center for Integrative Inflammology, The University of Tokyo, Tokyo, Japan

Keishi Fujio

Affiliation Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Hiroaki Okazaki

Affiliation Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Seitaro Nomura

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Norifumi Takeda

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Mutsuo Harada

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Haruhiro Toko

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Eiki Takimoto

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Hiroshi Akazawa

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Hiroyuki Morita

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Jun-ichi Suzuki

Affiliation Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Tokyo, Japan

Tsutomu Yamazaki

Affiliation Clinical Research Support Center, The University of Tokyo, Tokyo, Japan

Kazuhiko Yamamoto

Affiliation Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Issei Komuro

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Masashi Yanagisawa

Affiliations Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HK YI. Performed the experiments: HK YI TO YM. Analyzed the data: HK YI YM. Contributed reagents/materials/analysis tools: HK YI YM MF TO KF HO SN NT MH HT ET HA HM JS TY KY IK MY. Wrote the paper: HK YI YM.