About the Authors

Amber Dahlin

amber.dahlin@channing.harvard.edu

Affiliation Channing Division of Network Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, United States of America

Augusto Litonjua

Affiliations Channing Division of Network Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, United States of America, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States of America

John J. Lima

Affiliation Nemours Children’s Clinic, Jacksonville, FL, United States of America

Mayumi Tamari

Affiliation Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan

Michiaki Kubo

Affiliation Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan

Charles G. Irvin

Affiliation University of Vermont, Burlington, VT, United States of America

Stephen P. Peters

Affiliation Wake Forest School of Medicine, Winston-Salem, NC, United States of America

Kelan G. Tantisira

Affiliations Channing Division of Network Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, United States of America, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States of America

Competing Interests

GlaxoSmithKline supported the conduct of the LOCCS Trial by providing funds to the American Lung Association. The authors received no relevant funding or financial support from GSK. There are no patents, products in development or marketed products related to this manuscript to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KGT AL AD. Performed the experiments: AD KGT. Analyzed the data: AD KGT MT MK AL. Contributed reagents/materials/analysis tools: SPP CGI JJL KGT AL. Wrote the paper: AD AL JJL KGT.