About the Authors

Xiaobei Zhao

Contributed equally to this work with: Xiaobei Zhao, Anyou Wang, D. Neil Hayes, Stergios J. Moschos

Affiliation Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Anyou Wang

Contributed equally to this work with: Xiaobei Zhao, Anyou Wang, D. Neil Hayes, Stergios J. Moschos

Affiliation Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Vonn Walter

Affiliation Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Nirali M. Patel

Affiliations Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America, Department of Pathology and Laboratory Medicine, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

David A. Eberhard

Affiliations Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America, Department of Pathology and Laboratory Medicine, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Michele C. Hayward

Affiliation Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Ashley H. Salazar

Affiliation Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Heejoon Jo

Affiliations Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America, Department of Biostatistics, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Matthew G. Soloway

Affiliation Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Matthew D. Wilkerson

Affiliations Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America, Department of Genetics, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Joel S. Parker

Affiliation Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Xiaoying Yin

Affiliation Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Guosheng Zhang

Affiliation Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Marni B. Siegel

Affiliation The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, United States of America

Gary B. Rosson

Affiliations Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, United States of America

H. Shelton Earp III

Affiliations Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America, Department of Medicine, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America, Department of Pharmacology, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Norman E. Sharpless

Affiliations Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America, Department of Genetics, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America, Department of Medicine, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Margaret L. Gulley

Affiliations Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America, Department of Pathology and Laboratory Medicine, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Karen E. Weck

Affiliations Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America, Department of Pathology and Laboratory Medicine, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

D. Neil Hayes

Contributed equally to this work with: Xiaobei Zhao, Anyou Wang, D. Neil Hayes, Stergios J. Moschos

Affiliations Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America, Department of Genetics, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America, Department of Medicine, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Stergios J. Moschos

Contributed equally to this work with: Xiaobei Zhao, Anyou Wang, D. Neil Hayes, Stergios J. Moschos

moschos@med.unc.edu

Affiliations Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America, Department of Medicine, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States of America

Competing Interests

Margaret L. Gulley is an advisor for Illumina, Inc. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: XZ AW MDW JSP MBS HSE NES MLG KEW DNH SJM. Performed the experiments: AW MCH AHS MGS MBS GBR. Analyzed the data: XZ AW NMP DAE HJ MDW JSP MBS GBR NES MLG KEW DNH SJM. Contributed reagents/materials/analysis tools: XZ AW NMP DAE VW MCH AHS HJ MGS MDW JSP XY GZ MBS HSE NES DNH. Wrote the paper: XZ MCH MDW MLG KEW DNH SJM.