About the Authors

Hideki Tagashira

Affiliation Research and Development Division, Toyo Shinyaku Co., Ltd., 7–28 Yayoigaoka, Tosu, Saga, 841–0005, Japan

Aki Miyamoto

Affiliation Research and Development Division, Toyo Shinyaku Co., Ltd., 7–28 Yayoigaoka, Tosu, Saga, 841–0005, Japan

Sei-ichi Kitamura

Affiliation Research and Development Division, Toyo Shinyaku Co., Ltd., 7–28 Yayoigaoka, Tosu, Saga, 841–0005, Japan

Masahito Tsubata

Affiliation Research and Development Division, Toyo Shinyaku Co., Ltd., 7–28 Yayoigaoka, Tosu, Saga, 841–0005, Japan

Kazuya Yamaguchi

Affiliation Research and Development Division, Toyo Shinyaku Co., Ltd., 7–28 Yayoigaoka, Tosu, Saga, 841–0005, Japan

Kinya Takagaki

Affiliation Research and Development Division, Toyo Shinyaku Co., Ltd., 7–28 Yayoigaoka, Tosu, Saga, 841–0005, Japan

Genji Imokawa

imokawag@dream.ocn.ne.jp

Affiliation Research Institute for Biological Functions, Chubu University, 1200 Matsumoto, Kasugai, Aichi, 487–8501, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HT GI. Performed the experiments: HT AM SK MT. Analyzed the data: HT AM SK. Contributed reagents/materials/analysis tools: KY KT. Wrote the paper: HT GI.