About the Authors

Veerle Kersemans

Veerle.Kersemans@oncology.ox.ac.uk

Affiliation Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom

Pavitra Kannan

Affiliation Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom

John S. Beech

Affiliation Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom

Russell Bates

Affiliation The Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom

Benjamin Irving

Affiliation The Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom

Stuart Gilchrist

Affiliation Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom

Philip D. Allen

Affiliation Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom

James Thompson

Affiliation Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom

Paul Kinchesh

Affiliation Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom

Christophe Casteleyn

Affiliation Laboratory for Applied Veterinary Morphology, Department of Veterinary Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Belgium

Julia Schnabel

Affiliation The Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom

Mike Partridge

Affiliation Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom

Ruth J. Muschel

Affiliation Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom

Sean C. Smart

Affiliation Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom

Competing Interests

The Image Registration Toolkit (IRTK) which was under license from Ixico Ltd did not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: VK P. Kannan MP RJM SCS. Performed the experiments: VK P. Kannan JSB JT. Analyzed the data: VK P. Kannan RB JT BI MP SCS. Contributed reagents/materials/analysis tools: VK P. Kannan JSB RB BI SG P. Kinchesh CC. Wrote the paper: VK P. Kannan JSB RB BI SG PDA JT P. Kinchesh CC JS MP RJM SCS. Review: VK P. Kannan JSB RB BI SG PDA JT P. Kinchesh CC JS MP RJM SCS. Interpretation of data: VK P. Kannan JSB RB BI SG PDA P. Kinchesh CC JS MP RJM SCS.