About the Authors

Lorenzo Di Cesare Mannelli

lorenzo.mannelli@unifi.it

Affiliation Department of Neuroscience, Psychology, Drug Research and Child Health—Neurofarba—Pharmacology and Toxicology Section, University of Florence, Florence, Italy

Alessandra Pacini

Affiliation Department of Experimental and Clinical Medicine—DMSC—Anatomy and Histology Section, University of Florence, Florence, Italy

Francesca Corti

Affiliation Department of Neuroscience, Psychology, Drug Research and Child Health—Neurofarba—Pharmacology and Toxicology Section, University of Florence, Florence, Italy

Serena Boccella

Affiliation Department of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Naples, Italy

Livio Luongo

Affiliation Department of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Naples, Italy

Emanuela Esposito

Affiliations Department of Biological and Environmental Sciences, University of Messina, Messina, Italy, Young Against Pain (YAP) group, Italy

Salvatore Cuzzocrea

Affiliation Department of Biological and Environmental Sciences, University of Messina, Messina, Italy

Sabatino Maione

Affiliation Department of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Naples, Italy

Antonio Calignano

Affiliation Department of Pharmacy, University of Naples “Federico II”, Naples, Italy

Carla Ghelardini

Affiliation Department of Neuroscience, Psychology, Drug Research and Child Health—Neurofarba—Pharmacology and Toxicology Section, University of Florence, Florence, Italy

Competing Interests

Prof. Salvatore Cuzzocrea is co-inventor on a patent application regarding PEA and PEA derivatives (Title: “Compositions and methods for the modulation of specific amidases for n-acylethanolamines for use in the therapy of inflammatory diseases”; Number: WO 2013121449A1). The other authors declare no conflict of interest. The authors adhere to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LDCM AP CG SM SC AC. Performed the experiments: LDCM FC AP LL SB EE. Analyzed the data: LDCM FC AP LL SB CG. Contributed reagents/materials/analysis tools: CG SM SC AC AP. Wrote the paper: LDCM FC AP SB LL EE SM SC AC CG.