About the Authors

Michael Baym

Contributed equally to this work with: Michael Baym, Sergey Kryazhimskiy, Tami D. Lieberman, Hattie Chung

Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Sergey Kryazhimskiy

Contributed equally to this work with: Michael Baym, Sergey Kryazhimskiy, Tami D. Lieberman, Hattie Chung

Affiliations Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America, FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America

Tami D. Lieberman

Contributed equally to this work with: Michael Baym, Sergey Kryazhimskiy, Tami D. Lieberman, Hattie Chung

Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Hattie Chung

Contributed equally to this work with: Michael Baym, Sergey Kryazhimskiy, Tami D. Lieberman, Hattie Chung

Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Michael M. Desai

mmdesai@fas.harvard.edu (MB); roy_kishony@hms.harvard.edu (RK)

Affiliations Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America, FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America, Department of Physics, Harvard University, Cambridge, Massachusetts, United States of America

Roy Kishony

mmdesai@fas.harvard.edu (MB); roy_kishony@hms.harvard.edu (RK)

Affiliations Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Faculty of Biology and Department of Computer Science, Technion-Israel Institute of Technology, Haifa, Israel

Competing Interests

This study was partially funding by Hoffman-LaRoche (RK). There are no further declarations relating to employment, consultancy, patents, products in development, or marketed products. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Author Contributions

Conceived and designed the experiments: MB SK TL HC MMD RK. Performed the experiments: MB SK TL HC. Analyzed the data: MB SK TL HC. Contributed reagents/materials/analysis tools: MMD RK. Wrote the paper: MB SK TL HC MMD RK.