About the Authors

Meher Majety

meher.majety@roche.com

Affiliation Discovery Oncology, Roche Innovation Center Penzberg, Pharmaceutical Research and Early Development, Penzberg, Germany

Leon P. Pradel

Affiliation Discovery Oncology, Roche Innovation Center Penzberg, Pharmaceutical Research and Early Development, Penzberg, Germany

Manuela Gies

Affiliation Discovery Oncology, Roche Innovation Center Penzberg, Pharmaceutical Research and Early Development, Penzberg, Germany

Carola H. Ries

Affiliation Discovery Oncology, Roche Innovation Center Penzberg, Pharmaceutical Research and Early Development, Penzberg, Germany

Competing Interests

The authors have the following interests: This study was funded internally by Roche Diagnostics GmbH, the employer of all authors. The anti-IGF1R antibody (R1507) and the anti-cMet antibody (Onartuzumab) are described in the patents US7572897 titled “Antibodies against Insulin-like growth factor I receptor and uses thereof” and US7476724 titled “Humanized anti-cMet antibodies” respectively. There are no products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: MM. Performed the experiments: MM LPP MG. Analyzed the data: MM. Wrote the paper: MM CHR.