About the Authors

Cheryl Carson

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Pichai Raman

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Jennifer Tullai

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Lei Xu

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Martin Henault

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Emily Thomas

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Sarita Yeola

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Jianmin Lao

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

Mark McPate

Affiliation Novartis Institutes for Biomedical Research, Horsham, United Kingdom

J. Martin Verkuyl

Affiliation Novartis Institutes for Biomedical Research, Horsham, United Kingdom

George Marsh

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Jason Sarber

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Adam Amaral

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Scott Bailey

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Danuta Lubicka

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Helen Pham

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Nicolette Miranda

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Jian Ding

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Hai-Ming Tang

Affiliation Novartis Institutes for Biomedical Research, East Hanover, New Jersey, United States of America

Haisong Ju

Affiliation Novartis Institutes for Biomedical Research, East Hanover, New Jersey, United States of America

Pamela Tranter

Affiliation Novartis Institutes for Biomedical Research, Horsham, United Kingdom

Nan Ji

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Philipp Krastel

Affiliation Novartis Institutes for Biomedical Research, Basel, Switzerland

Rishi K. Jain

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Andrew M. Schumacher

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

Joseph J. Loureiro

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Elizabeth George

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Giuliano Berellini

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Nathan T. Ross

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Simon M. Bushell

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Gül Erdemli

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Jonathan M. Solomon

jonathan.solomon@novartis.com

Affiliation Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Competing Interests

The authors are current or past employees of Novartis. This declaration does not alter the authors' adherence to all PLOS ONE policies regarding sharing data and materials. There are also no patents, products in development, or currently marketed products to declare.

Author Contributions

Conceived and designed the experiments: CC H-MT HJ PT NJ RKJ AMS EG GB NTR SMB GE JMS. Performed the experiments: JT LX MH ET SY JL MM MV GM JS AA SB GB. Analyzed the data: CC PR H-MT HJ JL JJL EG GB NTR SMB GE JMS. Contributed reagents/materials/analysis tools: CC DL HP NM JD NJ PK SMB. Wrote the paper: PR PT NTR SMB GE JMS.