About the Authors

Giselle L. Saulnier Sholler

giselle.sholler@helendevoschildrens.org (GS) or andre.bachmann@hc.msu.edu (AB)

Affiliations Helen DeVos Children’s Hospital, Grand Rapids, Michigan, United States of America, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, United States of America

Eugene W. Gerner

Affiliation Cancer Prevention Pharmaceuticals, Tucson, Arizona, United States of America

Genevieve Bergendahl

Affiliation Helen DeVos Children’s Hospital, Grand Rapids, Michigan, United States of America

Robert B. MacArthur

Affiliation Cancer Prevention Pharmaceuticals, Tucson, Arizona, United States of America

Alyssa VanderWerff

Affiliation Helen DeVos Children’s Hospital, Grand Rapids, Michigan, United States of America

Takamaru Ashikaga

Affiliation Medical Biostatistics, University of Vermont, Burlington, Vermont, United States of America

Jeffrey P. Bond

Affiliation Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, Vermont, United States of America

William Ferguson

Affiliation Cardinal Glennon Children's Hospital, St. Louis, Missouri, United States of America

William Roberts

Affiliation University of California San Diego School of Medicine and Rady Children's Hospital, San Diego, California, United States of America

Randal K. Wada

Affiliation Kapiolani Medical Center for Women and Children, Honolulu, Hawaii, United States of America

Don Eslin

Affiliation Arnold Palmer Hospital for Children, Orlando, Florida, United States of America

Jacqueline M. Kraveka

Affiliation Medical University of South Carolina, Charleston, South Carolina, United States of America

Joel Kaplan

Affiliation Levine Children's Hospital, Charlotte, North Carolina, United States of America

Deanna Mitchell

Affiliation Helen DeVos Children’s Hospital, Grand Rapids, Michigan, United States of America

Nehal S. Parikh

Affiliation Connecticut Children's Medical Center, Hartford, Connecticut, United States of America

Kathleen Neville

Affiliation Children's Mercy Hospitals and Clinics, Kansas City, Missouri, United States of America

Leonard Sender

Affiliation Children’s Hospital of Orange County, Orange, California, United States of America

Timothy Higgins

Affiliation Medical Biostatistics, University of Vermont, Burlington, Vermont, United States of America

Masao Kawakita

Affiliation Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

Kyoko Hiramatsu

Affiliation Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

Shun-suke Moriya

Affiliation Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

André S. Bachmann

giselle.sholler@helendevoschildrens.org (GS) or andre.bachmann@hc.msu.edu (AB)

Affiliations College of Human Medicine, Michigan State University, Grand Rapids, Michigan, United States of America, University of Hawaii at Hilo, The Daniel K. Inouye College of Pharmacy, Hilo, Hawaii, United States of America

Competing Interests

The authors of this manuscript have the following competing interests: E.W.G. is a paid employee of Cancer Prevention Pharmaceuticals (CPP). He has an ownership interest in, and serves on the board of, CPP. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: GS ASB GB EWG DE TA. Performed the experiments: GS EWG MK KH SM DE AV WF WR RW J. Kraveka J. Kaplan DM NP KN LS JB TH. Analyzed the data: GS ASB GB EWG MK RBM TA TH. Contributed reagents/materials/analysis tools: TA WF WR RW J. Kraveka J. Kaplan DM NP KN LS JB. Wrote the paper: GS ASB GB EWG DE AV WF WR RW J. Kraveka J. Kaplan DM NP KN LS MK SM KH JB TH.