About the Authors

Christy L. Strong

‡ These authors contributed equally to this work and should be considered first authors.

Affiliation Nevada Institute of Personalized Medicine and School of Life Sciences, University of Nevada Las Vegas, Las Vegas, NV, United States of America

Horacio P. Guerra

‡ These authors contributed equally to this work and should be considered first authors.

Affiliation Nevada Institute of Personalized Medicine and School of Life Sciences, University of Nevada Las Vegas, Las Vegas, NV, United States of America

Kiran R. Mathew

Affiliation Nevada Institute of Personalized Medicine and School of Life Sciences, University of Nevada Las Vegas, Las Vegas, NV, United States of America

Nervik Roy

Affiliation Nevada Institute of Personalized Medicine and School of Life Sciences, University of Nevada Las Vegas, Las Vegas, NV, United States of America

Lacy R. Simpson

Affiliation Nevada Institute of Personalized Medicine and School of Life Sciences, University of Nevada Las Vegas, Las Vegas, NV, United States of America

Martin R. Schiller

martin.schiller@unlv.edu

Affiliation Nevada Institute of Personalized Medicine and School of Life Sciences, University of Nevada Las Vegas, Las Vegas, NV, United States of America

Competing Interests

This study is part of a pending patent application (US20140072961, WO2014011817A2) to the U.S. Patent and Trademark Office entitled “Genome surgery with paired, permeant endonuclease excision” authored by MRS and CLS. This intellectual property is owned by The Board of Reagents of the Nevada System of Higher Education on Behalf of the University of Nevada, Las Vegas. This does not alter the authors’ adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CLS HPG MRS. Performed the experiments: CLS HPG KRM NR LRS. Analyzed the data: CLS HPG MRS. Contributed reagents/materials/analysis tools: HPG MRS. Wrote the paper: CLS HPG MRS.