About the Authors

Claes Bavik

Affiliation Acucela, Inc., 1301 2nd Avenue, Suite 1900, Seattle, Washington 98101, United States of America

Susan Hayes Henry

Affiliation Acucela, Inc., 1301 2nd Avenue, Suite 1900, Seattle, Washington 98101, United States of America

Yan Zhang

Affiliation Acucela, Inc., 1301 2nd Avenue, Suite 1900, Seattle, Washington 98101, United States of America

Kyoko Mitts

Affiliation Acucela, Inc., 1301 2nd Avenue, Suite 1900, Seattle, Washington 98101, United States of America

Tim McGinn

Affiliation Acucela, Inc., 1301 2nd Avenue, Suite 1900, Seattle, Washington 98101, United States of America

Ewa Budzynski

Affiliation Acucela, Inc., 1301 2nd Avenue, Suite 1900, Seattle, Washington 98101, United States of America

Andriy Pashko

Affiliation Acucela, Inc., 1301 2nd Avenue, Suite 1900, Seattle, Washington 98101, United States of America

Kuo Lee Lieu

Affiliation Acucela, Inc., 1301 2nd Avenue, Suite 1900, Seattle, Washington 98101, United States of America

Sheng Zhong

Affiliation Acucela, Inc., 1301 2nd Avenue, Suite 1900, Seattle, Washington 98101, United States of America

Bruce Blumberg

Affiliation University of California, Irvine, School of Biological Sciences, 4351 Natural Sciences II, Irvine, California 92697, United States of America

Vladimir Kuksa

Affiliation Acucela, Inc., 1301 2nd Avenue, Suite 1900, Seattle, Washington 98101, United States of America

Mark Orme

Affiliation Acucela, Inc., 1301 2nd Avenue, Suite 1900, Seattle, Washington 98101, United States of America

Ian Scott

Affiliation Acucela, Inc., 1301 2nd Avenue, Suite 1900, Seattle, Washington 98101, United States of America

Ahmad Fawzi

Affiliation Acucela, Inc., 1301 2nd Avenue, Suite 1900, Seattle, Washington 98101, United States of America

Ryo Kubota

rkubota@acucela.com

Affiliation Acucela, Inc., 1301 2nd Avenue, Suite 1900, Seattle, Washington 98101, United States of America

Competing Interests

The authors declare the following competing financial interests: Acucela Inc. is the sponsor of all research described, and holds a financial interest in emixustat hydrochloride. Acucela Inc. and Otsuka provided funding towards this study. All co-authors were employees or contractors of Acucela Inc. at the time the research was performed. Author R. Kubota is the Founder, President, CEO and sits on the Board of Directors of Acucela Inc. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CB SHH EB SZ BB VK MO IS AF. Performed the experiments: SHH YZ KM TM EB AP KLL SZ BB VK. Analyzed the data: CB SHH YZ KM TM EB AP KLL SZ BB VK MO IS AF RK. Contributed reagents/materials/analysis tools: CB BB VK MO IS. Wrote the paper: SHH CB MO.