About the Authors

Anne-Mari Moilanen

Contributed equally to this work with: Anne-Mari Moilanen, Jaana Rysä

Affiliations The Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland, Department of Pathology, The Institute of Diagnostics, University of Oulu, Oulu, Finland, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland

Jaana Rysä

Contributed equally to this work with: Anne-Mari Moilanen, Jaana Rysä

Affiliation The Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland

Leena Kaikkonen

Affiliation The Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland

Teemu Karvonen

Affiliation The Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland

Erja Mustonen

Affiliation The Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland

Raisa Serpi

Affiliations The Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland, Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland

Zoltán Szabó

Affiliation The Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland

Olli Tenhunen

Affiliation The Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland

Zsolt Bagyura

Affiliation Heart Center, Semmelweis University, Budapest, Hungary

Juha Näpänkangas

Affiliation Department of Pathology, The Institute of Diagnostics, University of Oulu, Oulu, Finland

Pauli Ohukainen

Affiliation The Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland

Pasi Tavi

Affiliation Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

Risto Kerkelä

Affiliations The Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland

Margrét Leósdóttir

Affiliations Department of Clinical Sciences, Lund University, Lund, Sweden, Department of Cardiology, Skåne University Hospital, Malmö, Sweden

Björn Wahlstrand

Affiliation Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Thomas Hedner

Affiliation Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Olle Melander

Affiliations Department of Clinical Sciences, Lund University, Lund, Sweden, Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden

Heikki Ruskoaho

heikki.ruskoaho@helsinki.fi

Affiliations The Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland, Division of Pharmacology and Pharmacotherapy, University of Helsinki, Helsinki, Finland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AMM JR OM HR. Performed the experiments: AMM JR LK TK EM RS ZS OT ZB PT. Analyzed the data: AMM JR LK EM RS ZS OT ZB JN PO PT RK ML BW OM. Contributed reagents/materials/analysis tools: RK ML BW TH OM HR. Wrote the paper: AMM JR TH OM HR.