About the Authors

Braden Kuo

Contributed equally to this work with: Braden Kuo, Manoj Bhasin

‡ BK and MB are first authors on this work. TAL, JK, and JWD also contributed equally to this work and are senior authors on this work.

Affiliation Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Manoj Bhasin

Contributed equally to this work with: Braden Kuo, Manoj Bhasin

‡ BK and MB are first authors on this work. TAL, JK, and JWD also contributed equally to this work and are senior authors on this work.

Affiliations Division of Interdisciplinary Medicine & Biotechnology, and Genomics, Proteomics, Bioinformatics and Systems Biology Center, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Jolene Jacquart

Affiliation Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Matthew A. Scult

Affiliation Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Lauren Slipp

Affiliation Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Eric Isaac Kagan Riklin

Affiliation Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Veronique Lepoutre

Affiliation Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Nicole Comosa

Affiliation Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Beth-Ann Norton

Affiliation Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Allison Dassatti

Affiliation Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Jessica Rosenblum

Affiliation Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Andrea H. Thurler

Affiliation Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Brian C. Surjanhata

Affiliation Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Nicole N. Hasheminejad

Affiliation Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Leslee Kagan

Affiliation Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Ellen Slawsby

Affiliation Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Sowmya R. Rao

Affiliations Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Center for Healthcare Organization and Implementation Research (CHOIR), Bedford VA Medical Center, Bedford, Massachusetts, United States of America

Eric A. Macklin

Affiliation MGH Biostatistics Center, Massachusetts General Hospital, Boston, MA, and Harvard Medical School, Boston, Massachusetts, United States of America

Gregory L. Fricchione

Affiliations Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Herbert Benson

Affiliations Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Towia A. Libermann

‡ BK and MB are first authors on this work. TAL, JK, and JWD also contributed equally to this work and are senior authors on this work.

Affiliations Division of Interdisciplinary Medicine & Biotechnology, and Genomics, Proteomics, Bioinformatics and Systems Biology Center, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Joshua Korzenik

‡ BK and MB are first authors on this work. TAL, JK, and JWD also contributed equally to this work and are senior authors on this work.

Affiliations Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

John W. Denninger

jdenninger@mgh.harvard.edu

‡ BK and MB are first authors on this work. TAL, JK, and JWD also contributed equally to this work and are senior authors on this work.

Affiliations Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Competing Interests

The authors have the following conflicts to report: Dr. Kuo consults for Genova Diagnostics, Furiex, and Given Imaging. Dr. Kuo receives funding from Given and Furiex for clinical trials, unrelated to this particular study. Dr. Macklin serves on the DSMBs for Lantheus Medical Imaging, Shire Human Genetic Therapies, and Civitas Therapeutics. Dr. Denninger receives support for unrelated investigator-initiated studies from Onyx Pharmaceuticals and Basis. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BK MB EAM GLF HB TAL JK JWD NNH ES. Performed the experiments: MAS LS VL NC BAN AD JR AHT BCS NNH LK ES BK LK. Analyzed the data: SRR EAM TAL JK JWD BK MB JJ NC NNH. Contributed reagents/materials/analysis tools: MB BK. Wrote the paper: MAS BK GLF MB SSR TAL JJ JK JWD. Insert "Reviewed and edited data, results, and manuscripts: ES NC HB BCS LS NH LK EIKR.