About the Authors

Yian Gu

yg2121@columbia.edu

Affiliation The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York, United States of America

Qolamreza R. Razlighi

Affiliation The Department of Neurology, Columbia University, New York, New York, United States of America

Laura B. Zahodne

Affiliation The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York, United States of America

Sarah C. Janicki

Affiliation The Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America

Masanori Ichise

Affiliation Department of Radiology, Columbia University Medical College, New York, New York, United States of America

Jennifer J. Manly

Affiliations The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York, United States of America, The Department of Neurology, Columbia University, New York, New York, United States of America, The Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America

D. P. Devanand

Affiliation Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, United States of America

Adam M. Brickman

Affiliations The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York, United States of America, The Department of Neurology, Columbia University, New York, New York, United States of America, The Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America

Nicole Schupf

Affiliations The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York, United States of America, The Department of Neurology, Columbia University, New York, New York, United States of America, The Division of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, New York, United States of America

Richard Mayeux

Affiliations The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York, United States of America, The Department of Neurology, Columbia University, New York, New York, United States of America, The Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America, The Division of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, New York, United States of America

Yaakov Stern

Affiliations The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York, United States of America, The Department of Neurology, Columbia University, New York, New York, United States of America, The Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America

Competing Interests

Dr. Ichise has been a consultant for Piramal, Navidea Biopharmaceuticals, and Molecular Neuroimaging Institute and has received research support and/or consultancy fees. Dr. Manly serves on the Medical and Scientific Advisory Board of the Alzheimer's Association. She serves on the US Department of Health and Human Services Advisory Council on Alzheimer's Research, Care and Services. Her scientific work is funded by grants from NIH and the Alzheimer's Association. Dr. Devanand has served as a consultant to AbbVie and Lundbeck. Dr. Brickman is on the Scientific Advisory Boards and serves as a paid consultant for ProPhase, LLC and Keystone Heart, LLC. He serves on the Board of Directors of the International Neuropsychological Society, which has paid for his travel to annual meetings. He is supported by grants from NIH, the Groff Foundation, Mars Inc, and Columbia University. Dr. Stern was on the advisory committee for Janssen Alzheimer Immunotherapy Research & Development, LLC. He serves on the Advisory Board for AbbVie, Inc, and is a consultant for Eli Lilly, Takeda, and Piramal. His scientific work is funded by NIH grants R01AG007370, R01AG038465, R01AG033546, and R01AG026158. Dr. Stern served on the Advisory Board of the Alzheimer's Association. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YG YS. Performed the experiments: QRR SCJ MI YS. Analyzed the data: YG LBZ. Wrote the paper: YG. Collected data: JJM AMB NS RM YS. Provided significant advice and consultation: JJM DPD AMB NS RM YS. Provided critical review of the manuscript: QRR LBZ SCJ MI JJM DPD AMB NS RM YS.