About the Authors

Hongsheng Xie

Current address: Hangzhou DAC Biotech Co, Ltd. B2005, No. 452 Sixth Street, HEDA Area, Hangzhou, China

Affiliation Shire, Lexington, Massachusetts, United States of America

Jou-Ku Chung

jchung@shire.com

Affiliation Shire, Lexington, Massachusetts, United States of America

Mary Ann Mascelli

Affiliation Shire, Lexington, Massachusetts, United States of America

Thomas G. McCauley

Affiliation Shire, Lexington, Massachusetts, United States of America

Competing Interests

Jou-Ku Chung, Mary Ann Mascelli, and Thomas G. McCauley are employees and own stock in Shire. Hongsheng Xie was an employee of Shire at the time of the study. The authors affirm that these are accurate descriptions for all the authors and this does not alter their adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HX J-KC MAM TGM. Performed the experiments: HX J-KC MAM TGM. Analyzed the data: HX J-KC MAM TGM. Contributed reagents/materials/analysis tools: HX J-KC MAM TGM. Wrote the paper: HX J-KC MAM TGM.