About the Authors

Brian M. Necela

Affiliation Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United Sates of America

Jennifer A. Crozier

Affiliation Department of Hematology and Oncology, Mayo Clinic, Jacksonville, Florida, United States of America

Cathy A. Andorfer

Affiliation Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United Sates of America

Laura Lewis-Tuffin

Affiliation Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United Sates of America

Jennifer M. Kachergus

Affiliation Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United Sates of America

Xochiquetzal J. Geiger

Affiliation Department of Pathology and Laboratory Medicine, Mayo Clinic, Jacksonville, Florida, United States of America

Krishna R. Kalari

Affiliation Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America

Daniel J. Serie

Affiliation Department of Health Sciences Research, Mayo Clinic, Jacksonville, Florida United States of America

Zhifu Sun

Affiliation Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America

Alvaro Moreno Aspita

Affiliation Department of Hematology and Oncology, Mayo Clinic, Jacksonville, Florida, United States of America

Daniel J. O’Shannessy

Affiliation Department of Translational Medicine and Diagnostics, Morphotek, Exton, Pennsylvania, United States of America

Julia D. Maltzman

Affiliation Department of Clinical Development, Morphotek, Exton, Pennsylvania, United States of America

Ann E. McCullough

Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, Arizona, United States of America

Barbara A. Pockaj

Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, Arizona, United States of America

Heather E. Cunliffe

Affiliation Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand

Karla V. Ballman

Affiliation Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America

E. Aubrey Thompson

thompson.aubrey@mayo.edu

Affiliation Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United Sates of America

Edith A. Perez

Affiliation Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United Sates of America

Competing Interests

The authors confirm that “Daniel J. O’Shannessy and Julia D. Maltzman are employees of Morphotek, developers of the FOLR1 antibody farletuzumab and as such have received support in the form of salaries from Morphotek. Daniel J. O’Shannessy and Julia D. Maltzman did not have any additional role in the data collection and analysis, manuscript preparation or decision to publish. However, both were involved in minor aspects of study design by providing protocols and technical advice on staining tissues for folate receptor expression (Fig. 3). Data collection, data interpretation, manuscript preparation and the decision to publish resided exclusively with Mayo Clinic investigators. The inclusion of Daniel J. O’Shannessy and Julia D. Maltzman as coauthors does not alter the authors' adherence to PLOS One policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BMN EAT EAP AMA CAA. Performed the experiments: BMN LLT CAA JMK XJG KRK ZS. Analyzed the data: BMN EAT LLT CAA JAC KVB DJS. Contributed reagents/materials/analysis tools: JDM AEM BAP HEC DJO. Wrote the paper: BMN EAT.