About the Authors

Toshiaki Ohkuma

Affiliations Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Masanori Iwase

iwase@intmed2.med.kyushu-u.ac.jp

Affiliations Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Diabetes Center, Hakujyuji Hospital, Fukuoka, Japan

Hiroki Fujii

Affiliation Division of General Internal Medicine, School of Oral Health Science, Kyushu Dental University, Kitakyushu, Japan

Shinako Kaizu

Affiliation Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Hitoshi Ide

Affiliation Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Tamaki Jodai

Affiliation Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Yohei Kikuchi

Affiliation Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Yasuhiro Idewaki

Affiliation Diabetes Center, Hakujyuji Hospital, Fukuoka, Japan

Yoichiro Hirakawa

Affiliation Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Udai Nakamura

Affiliation Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Takanari Kitazono

Affiliation Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Competing Interests

A Japan Heart Foundation and Astellas/Pfizer Grant partly funded this study. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TO HF MI. Performed the experiments: TO MI. Analyzed the data: TO MI. Wrote the paper: TO MI. Helped with interpreting the data and contributed to the discussion: HF SK HI TJ YK YI YH UN TK. Participated in critically revising the manuscript and approved the final version: TO MI HF SK HI TJ YK YI YH UN TK.