About the Authors

Ralph Pannell

Affiliation Vascular Research Laboratory, Mount Auburn Hospital, Harvard Medical School, Cambridge, Massachusetts, United States of America

Shelley Li

Affiliation Vascular Research Laboratory, Mount Auburn Hospital, Harvard Medical School, Cambridge, Massachusetts, United States of America

Victor Gurewich

vgurewich@tsillc.net

Affiliation Vascular Research Laboratory, Mount Auburn Hospital, Harvard Medical School, Cambridge, Massachusetts, United States of America

Competing Interests

Victor Gurewich, M.D., is the Chief Scientific Officer of Thrombolytic Science International, LLC which is developing mutant proUK, and confirms that his position at Thrombolytic Science International does not alter the authors' adherence to PLOS ONE policies in sharing data and/or materials.

Author Contributions

Conceived and designed the experiments: VG RP. Performed the experiments: VG RP SL. Analyzed the data: RP VG. Wrote the paper: VG RP.