Lipophilic Triphenylphosphonium Cations Inhibit Mitochondrial Electron Transport Chain and Induce Mitochondrial Proton Leak

Jan Trnka; Moustafa Elkalaf; Michal Anděl

doi:10.1371/journal.pone.0121837

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Open Access

Peer-reviewed

Research Article

Lipophilic Triphenylphosphonium Cations Inhibit Mitochondrial Electron Transport Chain and Induce Mitochondrial Proton Leak

Jan Trnka ,

Contributed equally to this work with: Jan Trnka, Moustafa Elkalaf

* E-mail: jan.trnka@lf3.cuni.cz

Affiliations Laboratory for Metabolism and Bioenergetics, Third Faculty of Medicine, Charles University, Prague, Czech Republic, Centre for Research on Diabetes, Metabolism and Nutrition, Third Faculty of Medicine, Charles University, Prague, Czech Republic
⨯
Moustafa Elkalaf ,

Contributed equally to this work with: Jan Trnka, Moustafa Elkalaf

Affiliations Laboratory for Metabolism and Bioenergetics, Third Faculty of Medicine, Charles University, Prague, Czech Republic, Centre for Research on Diabetes, Metabolism and Nutrition, Third Faculty of Medicine, Charles University, Prague, Czech Republic
⨯
Michal Anděl

Affiliation Centre for Research on Diabetes, Metabolism and Nutrition, Third Faculty of Medicine, Charles University, Prague, Czech Republic
⨯

Lipophilic Triphenylphosphonium Cations Inhibit Mitochondrial Electron Transport Chain and Induce Mitochondrial Proton Leak

Jan Trnka,
Moustafa Elkalaf,
Michal Anděl

Published: April 30, 2015
https://doi.org/10.1371/journal.pone.0121837

About the Authors

Jan Trnka

Contributed equally to this work with: Jan Trnka, Moustafa Elkalaf

* E-mail: jan.trnka@lf3.cuni.cz

Affiliations Laboratory for Metabolism and Bioenergetics, Third Faculty of Medicine, Charles University, Prague, Czech Republic, Centre for Research on Diabetes, Metabolism and Nutrition, Third Faculty of Medicine, Charles University, Prague, Czech Republic

Moustafa Elkalaf

Contributed equally to this work with: Jan Trnka, Moustafa Elkalaf

Michal Anděl

Affiliation Centre for Research on Diabetes, Metabolism and Nutrition, Third Faculty of Medicine, Charles University, Prague, Czech Republic

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JT ME MA. Performed the experiments: JT ME. Analyzed the data: JT ME. Wrote the paper: JT ME MA.

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Mitochondria
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Membrane potential
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Mitochondrial membrane
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Protons
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Cations
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Membrane protein complexes
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Skeletal muscles
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Phospholipids
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