About the Authors

Guoqing Wang

Contributed equally to this work with: Guoqing Wang, Rui Wang

Current address: Mitsubishi Tanabe

Affiliation Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America

Rui Wang

Contributed equally to this work with: Guoqing Wang, Rui Wang

Affiliation Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America

Yael Strulovici-Barel

Affiliation Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America

Jacqueline Salit

Affiliation Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America

Michelle R. Staudt

Affiliation Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America

Joumana Ahmed

Affiliation Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America

Ann E. Tilley

Affiliations Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York, United States of America

Jenny Yee-Levin

Affiliation Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America

Charleen Hollmann

Affiliation Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America

Ben-Gary Harvey

Affiliations Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York, United States of America

Robert J. Kaner

Affiliations Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York, United States of America

Jason G. Mezey

Affiliations Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America, Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

Sriram Sridhar

Affiliation Hoffman-La Roche, Inc, Nutley, New Jersey, United States of America

Sreekumar G. Pillai

Current address: Eli Lilly and Company

Affiliation Hoffman-La Roche, Inc, Nutley, New Jersey, United States of America

Holly Hilton

Current address: PPD Labs

Affiliation Hoffman-La Roche, Inc, Nutley, New Jersey, United States of America

Gerhard Wolff

Affiliation Hoffman-La Roche, Inc, Nutley, New Jersey, United States of America

Hans Bitter

Current address: Novartis

Affiliation Hoffman-La Roche, Inc, Nutley, New Jersey, United States of America

Sudha Visvanathan

Current address: Boehringer-Ingelheim Pharmaceuticals

Affiliation Hoffman-La Roche, Inc, Nutley, New Jersey, United States of America

Jay S. Fine

Current address: Boehringer-Ingelheim Pharmaceuticals

Affiliation Hoffman-La Roche, Inc, Nutley, New Jersey, United States of America

Christopher S. Stevenson

Affiliation Hoffman-La Roche, Inc, Nutley, New Jersey, United States of America

Ronald G. Crystal

geneticmedicine@med.cornell.edu

Affiliations Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York, United States of America

Competing Interests

This study was partly supported by Hoffmann-La Roche, the previous employer of SS, SGP, HH, G. Wolff, HB, SV, JSF and CSS. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: G. Wang RW JSF CSS RGC. Performed the experiments: JA AET JYL CH BGH RJK. Analyzed the data: G. Wang RW YSB JS MrS AET JGM SS SGP HH G. Wolff. Contributed reagents/materials/analysis tools: SS SGP HH G. Wolff HB SV JSF CSS RGC. Wrote the paper: G. Want RW YSB RGC.