About the Authors
- Hadrien Peyret
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Affiliation Department of Biological Chemistry, John Innes Centre, Norwich, United Kingdom
- Annick Gehin
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Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
- Eva C. Thuenemann
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Affiliation Department of Biological Chemistry, John Innes Centre, Norwich, United Kingdom
- Donatienne Blond
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Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
- Aadil El Turabi
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Affiliations School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom, iQur Ltd, London, United Kingdom
- Lucy Beales
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Affiliations School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom, iQur Ltd, London, United Kingdom
- Dean Clarke
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Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
- Robert J. C. Gilbert
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Affiliation UK Division of Structural Biology, University of Oxford, Oxford, United Kingdom
- Elizabeth E. Fry
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Affiliation UK Division of Structural Biology, University of Oxford, Oxford, United Kingdom
- David I. Stuart
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Affiliation UK Division of Structural Biology, University of Oxford, Oxford, United Kingdom
- Kris Holmes
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Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
- Nicola J. Stonehouse
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Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
- Mike Whelan
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Affiliation iQur Ltd, London, United Kingdom
- William Rosenberg
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Affiliation iQur Ltd, London, United Kingdom
- George P. Lomonossoff
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Affiliation Department of Biological Chemistry, John Innes Centre, Norwich, United Kingdom
- David J. Rowlands
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* E-mail: D.j.rowlands@leeds.ac.uk
Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
Competing Interests
Aadil El Turabi, Lucy Beales, and Mike Whelan are employed by iQur Ltd., which was founded by William Rosenberg who is Chief Scientific and Executive Director. The company is using tandem core technology in the development of vaccines. In addition, A.G., D.J.R., R.J.C.G., and D.I.S. are named inventors on patent EPO EP1268530/A1, "Hepatitis B core antigen fusion proteins", which relates to the tandem core system; and D.J.R., G.P.L., and H.P. are named inventors on patent PCT/GB2014/051739, "Single domain antibody display", which relates to the display of single-domain nanobodies on the surface of tandem core VLPs. There are no further patents, products in development, or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Author Contributions
Conceived and designed the experiments: HP AG ECT DB AET LB DC RJCG EEF DIS KH NJS MW WR GPL DJR. Performed the experiments: HP AG ECT DB AET LB DC RJCG EEF KH NJS. Analyzed the data: HP AG ECT DB AET LB DC RJCG EEF DIS KH NJS MW WR GPL DJR. Wrote the paper: HP AG ECT LB RJCG DIS KH NJS MW GPL DJR.