About the Authors

Mitsuhiro Yoshita

Affiliations Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920–8640, Japan, Department of Neurology, Hokuriku National Hospital, Nanto, Toyama 939–1893, Japan

Heii Arai

Affiliation Department of Psychiatry, Juntendo University School of Medicine, Bunkyo, Tokyo 113–8431, Japan

Hiroyuki Arai

Affiliation Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi 980–8575, Japan

Tetsuaki Arai

Affiliation Department of Neuropsychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaragi 305–8576, Japan

Takashi Asada

Affiliation Department of Neuropsychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaragi 305–8576, Japan

Hiroshige Fujishiro

Affiliation PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Koto, Tokyo 136–0075, Japan

Haruo Hanyu

Affiliation Department of Geriatric Medicine, Tokyo Medical University, Shinjuku, Tokyo 160–0023, Japan

Osamu Iizuka

Affiliation Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980–8575, Japan

Eizo Iseki

Affiliation PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Koto, Tokyo 136–0075, Japan

Kenichi Kashihara

Affiliation Department of Neurology, Okayama Kyokuto Hospital, Okayama, Okayama 703–8265, Japan

Kenji Kosaka

Affiliation Medical Care Court Clinic, Yokohama, Kanagawa 225–0014, Japan

Hirotaka Maruno

Affiliation Department of Radiology, Toranomon Hospital, Minato, Tokyo 105–8470, Japan

Katsuyoshi Mizukami

Affiliation Graduate School of Comprehensive Human Sciences, University of Tsukuba, Bunkyo, Tokyo 112–0012, Japan

Yoshikuni Mizuno

Affiliation Department of Neurology, Division of Neurogenerative Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa 252–0374, Japan

Etsuro Mori

Affiliation Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980–8575, Japan

Kenichi Nakajima

Affiliation Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Ishikawa 920–8640, Japan

Hiroyuki Nakamura

Affiliation Department of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920–8640, Japan

Seigo Nakano

Affiliation Center for Treatment, Care and Research of Dementia, Medical Co. LTA, Sumida, Tokyo 130–0004, Japan

Kenji Nakashima

Affiliation Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Tottori 683–8504, Japan

Yoshiyuki Nishio

Affiliation Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980–8575, Japan

Satoshi Orimo

Affiliation Department of Neurology Kanto Central Hospital of the Mutual Aid Association of Public School Teachers, Setagaya, Tokyo 158–8531, Japan

Miharu Samuraki

Affiliation Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920–8640, Japan

Akira Takahashi

Affiliation Tokai Central Hospital, Kakamigahara, Gifu 504–0816, Japan

Junichi Taki

Affiliation Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Ishikawa 920–8640, Japan

Takahiko Tokuda

Affiliation Department of Molecular Pathobiology of Brain Diseases, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Kyoto 602–0841, Japan

Katsuya Urakami

Affiliation Department of Biological Regulation, School of Health Science, Faculty of Medicine, Tottori University, Yonago, Tottori 683–8503, Japan

Kumiko Utsumi

Affiliation Department of Neuropsychiatry, Sunagawa City Medical Center, Sunagawa, Hokkaido 073–0196, Japan

Kenji Wada

Affiliation Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Tottori 683–8504, Japan

Yukihiko Washimi

Affiliation Department for Cognitive Disorders, Hospital of National Center for Geriatrics and Gerontology, Obu, Aichi 474–8511, Japan

Junichi Yamasaki

Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, Ohmori Hospital, Toho University School of Medicine, Ota, Tokyo143–8541, Japan

Shouhei Yamashina

Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, Ohmori Hospital, Toho University School of Medicine, Ota, Tokyo143–8541, Japan

Masahito Yamada

m-yamada@med.kanazawa-u.ac.jp

Affiliation Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920–8640, Japan

Competing Interests

Mitsuhiro Yoshita, Kenji Wada and Seigo Nakano received honoraria for sponsored lectures from Fujifilm RI Pharma Co. Ltd. Takashi Asada and Shouhei Yamashina received honoraria for sponsored lectures and research grant from Fujifilm RI Pharma Co. Ltd. and Nihon Medi-Physics Co. Ltd. Haruo Hanyu, Junichi Taki and Takahiko Tokuda received honoraria for sponsored lectures from Nihon Medi-Physics Co. Ltd. Eizo Iseki received honoraria for consultancies, sponsored lectures, and presiding at lecture meetings from Nihon Medi-Physics Co. Ltd. Osamu Iizuka received honoraria and travel costs from Nihon Medi-Physics Co. Ltd. Kenji Kosaka received honoraria for sponsored lectures, writing, and editing from Fujifilm RI Pharma Co. Ltd., and honoraria for sponsored lectures from Nihon Medi-Physics Co. Ltd. Etsuo Mori and Katsuya Urakami received research grant from Fujifilm RI Pharma Co. Ltd., and honoraria for sponsored lectures from Nihon Medi-Physics Co. Ltd. Hirotaka Maruno received honoraria for sponsored lectures and travel costs from Fujifilm RI Pharma Co. Ltd. and Nihon Medi-Physics Co. Ltd. Kenichi Nakajima has collaborative research works with Fujifilm RI Pharma Co. Ltd., and received research funds for joint researches, honoraria for lectures and writing, and pending application for a patent on software development unrelated to this study; the title is "Image processing method and computer program” and the number is No. JP 2012–78088. Kenji Nakashima received sponsored scholarship and honoraria for presiding at lecture meetings from Fujifilm RI Pharma Co. Ltd. Satoshi Orimo received honoraria for sponsored lectures from Fujifilm RI Pharma Co. Ltd. and Nihon Medi-Physics Co. Ltd. Junichi Yamasaki received sponsored scholarship, honoraria for sponsored lectures, and travel costs from Fujifilm RI Pharma Co. Ltd., and honoraria for sponsored lectures and research grant from Nihon Medi-Physics Co. Ltd. Masahito Yamada received honoraria for sponsored lectures and research grant from Fujifilm RI Pharma Co. Ltd. Heii Arai, Hiroyuki Arai, Tetsuaki Arai, Hiroshige Fujishiro, Eizo Iseki, Kenichi Kashihara, Katsuyoshi Mizukami, Yoshikuni Mizuno, Hiroyuki Nakamura, Seigo Nakano, Yoshiyuki Nishio, Miharu Samuraki, Akira Takahashi, Kumiko Utsumi, Kenji Wada, and Yukihiko Washimi declare that they have no conflicts of interest. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: M. Yoshita Heii Arai K. Kosaka YM K. Nakajima HN AT JT JY M. Yamada. Performed the experiments: M. Yoshita T. Arai T. Asada HF HH OI EI K. Kashihara KM EM K. Nakajima YN MS TT K. Utsumi KW YW Hiroyuki Arai SN K. Urakami HM SO SY. Analyzed the data: M. Yoshita K. Nakajima MS. Wrote the paper: M. Yoshita K. Nakajima MS M. Yamada. Revised and approved the paper: M. Yoshita Heii Arai Hiroyuki Arai T. Arai T. Asada HF HH OI EI K. Kashihara K. Kosaka HM KM YM EM K. Nakajima HN SN K. Nakashima YN SO MS AT JT TT K. Urakami K. Utsumi KW YW JY SY M. Yamada.