Oral Administration of PF-01247324, a Subtype-Selective Nav1.8 Blocker, Reverses Cerebellar Deficits in a Mouse Model of Multiple Sclerosis

Shannon D. Shields; Richard P. Butt; Sulayman D. Dib-Hajj; Stephen G. Waxman

doi:10.1371/journal.pone.0119067

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Research Article

Oral Administration of PF-01247324, a Subtype-Selective Nav1.8 Blocker, Reverses Cerebellar Deficits in a Mouse Model of Multiple Sclerosis

Shannon D. Shields,

Affiliations Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut, United States of America, Rehabilitation Research Center, Veterans’ Affairs Connecticut Healthcare System, West Haven, Connecticut, United States of America
⨯
Richard P. Butt,

Affiliation Neusentis UK, Pfizer Global R&D, Cambridge, United Kingdom
⨯
Sulayman D. Dib-Hajj,

Affiliations Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut, United States of America, Rehabilitation Research Center, Veterans’ Affairs Connecticut Healthcare System, West Haven, Connecticut, United States of America
⨯
Stephen G. Waxman

* E-mail: stephen.waxman@yale.edu

Affiliations Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut, United States of America, Rehabilitation Research Center, Veterans’ Affairs Connecticut Healthcare System, West Haven, Connecticut, United States of America
⨯

Oral Administration of PF-01247324, a Subtype-Selective Nav1.8 Blocker, Reverses Cerebellar Deficits in a Mouse Model of Multiple Sclerosis

Shannon D. Shields,
Richard P. Butt,
Sulayman D. Dib-Hajj,
Stephen G. Waxman

Published: March 6, 2015
https://doi.org/10.1371/journal.pone.0119067

About the Authors

Shannon D. Shields

Affiliations Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut, United States of America, Rehabilitation Research Center, Veterans’ Affairs Connecticut Healthcare System, West Haven, Connecticut, United States of America

Richard P. Butt

Affiliation Neusentis UK, Pfizer Global R&D, Cambridge, United Kingdom

Sulayman D. Dib-Hajj

Stephen G. Waxman

* E-mail: stephen.waxman@yale.edu

Competing Interests

SDD-H: consultancy, Ono Pharmaceuticals, Guidepoint Global, Cardiome Pharm; patents, Yale University; stock/stock options, Pfizer. SGW: consultancy, Bristol Myers Squibb, Vertex Pharmaceuticals, ChromoCell Corp, DaiNippon Sumitomo Pharm, Cardiome Pharm; patents, Yale University. RPB is an employee of Pfizer Ltd. Patents held by Dr. Sulayman D. Dib-Hajj and Dr. Dr. Stephen G. Waxman through Yale University are: US Patent 6,573,067: Nucleic acid encoding sodium channels in dorsal root ganglia. European Union patent 05015946.6: Modulation of sodium channels in dorsal root ganglia. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SDS SDD-H SGW. Performed the experiments: SDS. Analyzed the data: SDS RPB SDD-H SGW. Contributed reagents/materials/analysis tools: RPB. Wrote the paper: SDS RPB SDD-H SGW.

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Multiple sclerosis
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Mouse models
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Genetically modified animals
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Mice
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Neurons
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Oral administration
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Cerebellum
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Collective animal behavior
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