About the Authors

Christina Vasalou

Current address: Pharmacokinetics Dynamics Metabolism, Pfizer, Cambridge, MA, United States of America

Affiliation Advanced Quantitative Sciences, Novartis, Cambridge, MA, United States of America

Gabriel Helmlinger

Current address: Quantitative Clinical Pharmacology, Waltham, MA, United States of America

Affiliation Advanced Quantitative Sciences, Novartis, Cambridge, MA, United States of America

Bruce Gomes

bruce.gomes@novartis.com

Affiliation Advanced Quantitative Sciences, Novartis, Cambridge, MA, United States of America

Competing Interests

At the time of these analyses, all authors were Novartis employees. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CV GH BG. Analyzed the data: CV. Contributed reagents/materials/analysis tools: CV. Wrote the paper: CV GH BG.