Using Visualized Matrix Effects to Develop and Improve LC-MS/MS Bioanalytical Methods, Taking TRAM-34 as an Example

Jia-Hung Ye; Li-Heng Pao

doi:10.1371/journal.pone.0118818

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Open Access

Peer-reviewed

Research Article

Using Visualized Matrix Effects to Develop and Improve LC-MS/MS Bioanalytical Methods, Taking TRAM-34 as an Example

Jia-Hung Ye,

Affiliation Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
⨯
Li-Heng Pao

* E-mail: paolhaa@gmail.com

Affiliations School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, Republic of China, Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan, Republic of China, Graduate Institute of Health-Industry Technology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan, Republic of China
⨯

Using Visualized Matrix Effects to Develop and Improve LC-MS/MS Bioanalytical Methods, Taking TRAM-34 as an Example

Jia-Hung Ye,
Li-Heng Pao

Published: April 24, 2015
https://doi.org/10.1371/journal.pone.0118818

About the Authors

Jia-Hung Ye

Affiliation Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China

Li-Heng Pao

* E-mail: paolhaa@gmail.com

Affiliations School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, Republic of China, Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan, Republic of China, Graduate Institute of Health-Industry Technology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan, Republic of China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JHY LHP. Performed the experiments: JHY. Analyzed the data: JHY LHP. Contributed reagents/materials/analysis tools: JHY LHP. Wrote the paper: JHY LHP.

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Phospholipids
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Elution
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Blood plasma
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Flow rate
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Lipids
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Computer software
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Data visualization
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Ionization
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