About the Authors

Renata J. M. Engler

renata.engler@gmail.com

Affiliations Military Vaccine Agency-Vaccine Healthcare Centers Network (currently Defense Health Agency, Immunization Healthcare Branch), Walter Reed National Military Medical Center, Bethesda, Maryland, United States of America, Department of Medicine and Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

Michael R. Nelson

Affiliations Department of Medicine and Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Allergy-Immunology-Immunizations, Walter Reed National Military Medical Center, Bethesda, Maryland, United States of America

Limone C. Collins Jr.

Affiliation Military Vaccine Agency-Vaccine Healthcare Centers Network (currently Defense Health Agency, Immunization Healthcare Branch), Walter Reed National Military Medical Center, Bethesda, Maryland, United States of America

Christina Spooner

Affiliation Military Vaccine Agency-Vaccine Healthcare Centers Network (currently Defense Health Agency, Immunization Healthcare Branch), Walter Reed National Military Medical Center, Bethesda, Maryland, United States of America

Brian A. Hemann

Affiliations Cardiology Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, United States of America, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

Barnett T. Gibbs

Affiliations Cardiology Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, United States of America, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

J. Edwin Atwood

Affiliations Cardiology Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, United States of America, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

Robin S. Howard

Affiliation Department of Research Programs, Walter Reed National Military Medical Center, Bethesda, Maryland, United States of America

Audrey S. Chang

Affiliation Department of Research Programs, Walter Reed National Military Medical Center, Bethesda, Maryland, United States of America

Daniel L. Cruser

Affiliation Department of Pathology, Vassar Brothers Medical Center, Poughkeepsie, New York, United States of America

Daniel G. Gates

Affiliation Cardiology Service, Fort Belvoir Community Hospital, Fort Belvoir, Virginia, United States of America

Marina N. Vernalis

Affiliation Integrated Cardiac Health Project, Walter Reed National Military Medical Center, Bethesda, Maryland, United States of America

Marguerite S. Lengkeek

Affiliation Allergy and Asthma Care Centers, Chantilly, Virginia, United States of America

Bruce M. McClenathan

Affiliation Military Vaccine Agency-Vaccine Healthcare Centers Network (currently Defense Health Agency, Immunization Healthcare Branch), Womack Army Medical Center, Fort Bragg, North Carolina, United States of America

Allan S. Jaffe

Affiliation Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America

Leslie T. Cooper

Affiliation Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America

Steve Black

Affiliation Cincinnati Children's Hospital Center for Global Health, Cincinnati, Ohio, United States of America

Christopher Carlson

Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Christopher Wilson

Current address: Bill and Melinda Gates Foundation, Seattle, Washington, United States of America

Affiliation Department of Immunology, University of Washington, Seattle, Washington, United States of America

Robert L. Davis

Affiliations Center for Biomedical Informatics, University of Tennessee Health Sciences Center, Memphis, Tennessee, United States of America, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America

Competing Interests

The authors of this manuscript have the following competing interests: Renata J. M. Engler: Study support as detailed under sources of funding. Allan S. Jaffe: Currently and in the past has consulted for most of the major diagnostic companies including the company that makes the assay used in this study. Leslie T. Cooper: Has consulted for Sanofi Pasteur, Inc. Christopher Carlson: Study support (NIH Grant) as detailed under sources of funding. Christopher Wilson: Study support (NIH Grant) as detailed under sources of funding. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RJME MRN LCC BAH BTG JEA RLD MNV SB CW. Performed the experiments: RJME MRN LCC BMM JEA BTG BAH DGG DLC. Analyzed the data: ASC RSH. Wrote the paper: RJME MRN LCC CS BAH BTG JEA RSH DLC ASC DGG MNV MSL BMM CW ASJ LTC CC RLD SB. Interpretation of data: RJME MRN LCC CS BAH BTG JEA DLC DGG MNV MSL BMM ASJ LTC SB CC RLD. Significant input and critical support for data analysis: RJME CS MRN CC RLD.