The Extracellular Loop 2 (ECL2) of the Human Histamine H4 Receptor Substantially Contributes to Ligand Binding and Constitutive Activity

David Wifling; Günther Bernhardt; Stefan Dove; Armin Buschauer

doi:10.1371/journal.pone.0117185

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Open Access

Peer-reviewed

Research Article

The Extracellular Loop 2 (ECL2) of the Human Histamine H₄ Receptor Substantially Contributes to Ligand Binding and Constitutive Activity

David Wifling,

Affiliation Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry II, University of Regensburg, Regensburg, Germany
⨯
Günther Bernhardt,

Affiliation Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry II, University of Regensburg, Regensburg, Germany
⨯
Stefan Dove,

Affiliation Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry II, University of Regensburg, Regensburg, Germany
⨯
Armin Buschauer

* E-mail: armin.buschauer@chemie.uni-regensburg.de

Affiliation Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry II, University of Regensburg, Regensburg, Germany
⨯

The Extracellular Loop 2 (ECL2) of the Human Histamine H₄ Receptor Substantially Contributes to Ligand Binding and Constitutive Activity

David Wifling,
Günther Bernhardt,
Stefan Dove,
Armin Buschauer

Published: January 28, 2015
https://doi.org/10.1371/journal.pone.0117185

About the Authors

David Wifling

Affiliation Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry II, University of Regensburg, Regensburg, Germany

Günther Bernhardt

Affiliation Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry II, University of Regensburg, Regensburg, Germany

Stefan Dove

Affiliation Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry II, University of Regensburg, Regensburg, Germany

Armin Buschauer

* E-mail: armin.buschauer@chemie.uni-regensburg.de

Affiliation Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry II, University of Regensburg, Regensburg, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DW GB SD AB. Performed the experiments: DW. Analyzed the data: DW GB SD AB. Contributed reagents/materials/analysis tools: GB SD. Wrote the paper: DW GB SD AB.

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Histamine
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G protein coupled receptors
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Cell binding assay
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Partial agonists
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Phenylalanine
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Receptor binding assays
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Disulfide bonds
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Insects
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