About the Authors

Faezeh Salehi

ssalehia@uci.edu (FS); pkaiser@uci.edu (PK)

‡ FS and RB contributed equally to this work. PK and RHL also contributed equally to this work.

Affiliations Department of Computer Science, University of California Irvine, Irvine, CA, 92697, United States of America, Institute for Genomics and Bioinformatics, University of California Irvine, Irvine, CA, 92697, United States of America

Roberta Baronio

‡ FS and RB contributed equally to this work. PK and RHL also contributed equally to this work.

Affiliations Department of Biological Chemistry, University of California Irvine, Irvine, CA, 92697, United States of America, Institute for Genomics and Bioinformatics, University of California Irvine, Irvine, CA, 92697, United States of America

Ryan Idrogo-Lam

Affiliation Department of Computer Science, University of California Irvine, Irvine, CA, 92697, United States of America

Huy Vu

Affiliation Department of Computer Science, University of California Irvine, Irvine, CA, 92697, United States of America

Linda V. Hall

Affiliations Department of Biological Chemistry, University of California Irvine, Irvine, CA, 92697, United States of America, Institute for Genomics and Bioinformatics, University of California Irvine, Irvine, CA, 92697, United States of America

Peter Kaiser

ssalehia@uci.edu (FS); pkaiser@uci.edu (PK)

‡ FS and RB contributed equally to this work. PK and RHL also contributed equally to this work.

Affiliations Department of Biological Chemistry, University of California Irvine, Irvine, CA, 92697, United States of America, Institute for Genomics and Bioinformatics, University of California Irvine, Irvine, CA, 92697, United States of America, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, United States of America

Richard H. Lathrop

‡ FS and RB contributed equally to this work. PK and RHL also contributed equally to this work.

Affiliations Department of Computer Science, University of California Irvine, Irvine, CA, 92697, United States of America, Institute for Genomics and Bioinformatics, University of California Irvine, Irvine, CA, 92697, United States of America, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, United States of America

Competing Interests

This work was supported by the National Institutes of Health under National Cancer Institute grant number R01CA112560 to R.H.L. and P.K. Principal Investigators R.H.L. and P.K. have an equity interest in Actavalon, Inc., and also serve on the Scientific Advisory Board. The terms of this arrangement have been reviewed and approved by the University of California, Irvine, in accordance with its conflict of interest policies. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: FS RB PK RHL. Performed the experiments: RB LH PK. Analyzed the data: FS RIL HV RHL. Contributed reagents/materials/analysis tools: FS RB RIL HV LH PK RHL. Wrote the paper: FS RB PK RHL.