About the Authors

Isabel Paiva

Affiliations Molecular Oncology and Viral Pathology Group, CI-IPOP, Portuguese Institute of Oncology of Porto, Rua Dr. António Bernardino de Almeida, 4200–072 Porto, Portugal, ICBAS, Abel Salazar Institute for the Biomedical Sciences, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050–313, Porto, Portugal

Rui M. Gil da Costa

Affiliations LEPABE, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias s/n, 4200–465, Porto, Portugal, Experimental Pathology and Therapeutics Group, CI-IPOP, Portuguese Institute of Oncology, Rua Dr. António Bernardino de Almeida, 4200–072 Porto, Portugal

Joana Ribeiro

Affiliations Molecular Oncology and Viral Pathology Group, CI-IPOP, Portuguese Institute of Oncology of Porto, Rua Dr. António Bernardino de Almeida, 4200–072 Porto, Portugal, Virology Service, Portuguese Institute of Oncology of Porto, Rua Dr. António Bernardino de Almeida, 4200–072 Porto, Portugal

Hugo Sousa

Affiliations Molecular Oncology and Viral Pathology Group, CI-IPOP, Portuguese Institute of Oncology of Porto, Rua Dr. António Bernardino de Almeida, 4200–072 Porto, Portugal, Virology Service, Portuguese Institute of Oncology of Porto, Rua Dr. António Bernardino de Almeida, 4200–072 Porto, Portugal

Margarida Bastos

Affiliation LEPABE, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias s/n, 4200–465, Porto, Portugal

Ana Faustino Carlos Rocha

Affiliations Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro, UTAD, Quinta de Prados, 5001–911, Vila Real, Portugal, Experimental Pathology and Therapeutics Group, CI-IPOP, Portuguese Institute of Oncology, Rua Dr. António Bernardino de Almeida, 4200–072 Porto, Portugal

Paula A Oliveira

Affiliations Veterinary Sciences Department, University of Trás-os-Montes and Alto Douro, UTAD, Quinta de Prados, 5001–801, Vila Real, Portugal, Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro, UTAD, Quinta de Prados, 5001–911, Vila Real, Portugal

Rui Medeiros

ruimedei@ipoporto.min-saude.pt

Affiliations Molecular Oncology and Viral Pathology Group, CI-IPOP, Portuguese Institute of Oncology of Porto, Rua Dr. António Bernardino de Almeida, 4200–072 Porto, Portugal, ICBAS, Abel Salazar Institute for the Biomedical Sciences, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050–313, Porto, Portugal, Virology Service, Portuguese Institute of Oncology of Porto, Rua Dr. António Bernardino de Almeida, 4200–072 Porto, Portugal, CEBIMED, Faculty of Health Sciences of Fernando Pessoa University, Porto, Portugal, Portuguese League Against Cancer (Liga Portuguesa Contra o Cancro–Núcleo Regional do Norte), Estrada Interior da Circunvalação, n°6657, 4200–177 Porto, Portugal

Competing Interests

Rui Medeiros, Molecular Oncology and Viral Pathology Group, Portuguese Institute of Oncology Asoociate Professor, ICBAS, Instituto Ciências Biomédicas Abel Salazar (University of Porto) is a PLOS ONE Editorial Board member. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: IP RGC RM. Performed the experiments: IP JR HS RGC CL AFR. Analyzed the data: IP RGC RM. Contributed reagents/materials/analysis tools: MB PO RM. Wrote the paper: IP RGC HS RM.