Helical Defects in MicroRNA Influence Protein Binding by TAR RNA Binding Protein

Roderico Acevedo; Nichole Orench-Rivera; Kaycee A. Quarles; Scott A. Showalter

doi:10.1371/journal.pone.0116749

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Open Access

Peer-reviewed

Research Article

Helical Defects in MicroRNA Influence Protein Binding by TAR RNA Binding Protein

Roderico Acevedo,

Affiliation Department of Chemistry and Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
⨯
Nichole Orench-Rivera,

Affiliation Department of Chemistry and Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
⨯
Kaycee A. Quarles,

Affiliation Department of Chemistry and Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
⨯
Scott A. Showalter

* E-mail: sas76@psu.edu

Affiliation Department of Chemistry and Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
⨯

Helical Defects in MicroRNA Influence Protein Binding by TAR RNA Binding Protein

Roderico Acevedo,
Nichole Orench-Rivera,
Kaycee A. Quarles,
Scott A. Showalter

Published: January 21, 2015
https://doi.org/10.1371/journal.pone.0116749

About the Authors

Roderico Acevedo

Affiliation Department of Chemistry and Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

Nichole Orench-Rivera

Affiliation Department of Chemistry and Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

Kaycee A. Quarles

Affiliation Department of Chemistry and Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

Scott A. Showalter

* E-mail: sas76@psu.edu

Affiliation Department of Chemistry and Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RA KAQ SAS. Performed the experiments: RA NOR KAQ. Analyzed the data: RA NOR KAQ SAS. Contributed reagents/materials/analysis tools: RA NOR KAQ SAS. Wrote the paper: RA NOR KAQ SAS.

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MicroRNAs
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Small interfering RNA
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Stoichiometry
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Electrophoretic mobility shift assay
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Binding analysis
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RNA-binding proteins
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Double stranded RNA
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RNA structure
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