About the Authors

Ralph S. DaCosta

rdacosta@uhnres.utoronto.ca

Affiliations Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto Medical Discovery Tower, 15th floor, 101 College St., Toronto, Ontario, M5G 1L7, Canada, Techna Institute for Advancement of Technologies for Health, University Health Network, 100 College Street, Rm. 124, Toronto, Ontario, M5G 1L5, Canada

Iris Kulbatski

Affiliation Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto Medical Discovery Tower, 15th floor, 101 College St., Toronto, Ontario, M5G 1L7, Canada

Liis Lindvere-Teene

Affiliation Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto Medical Discovery Tower, 15th floor, 101 College St., Toronto, Ontario, M5G 1L7, Canada

Danielle Starr

Affiliation Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto Medical Discovery Tower, 15th floor, 101 College St., Toronto, Ontario, M5G 1L7, Canada

Kristina Blackmore

Affiliation Prosserman Center for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 60 Murray Street, Box 18 Room 5–236, Toronto, Ontario, M5T 3L9, Canada

Jason I. Silver

Affiliation Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto Medical Discovery Tower, 15th floor, 101 College St., Toronto, Ontario, M5G 1L7, Canada

Julie Opoku

Affiliation The Judy Dan Treatment and Research Center, 555 Finch Avenue West, Toronto, Ontario, M2R 1N5, Canada

Yichao Charlie Wu

Affiliation Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto Medical Discovery Tower, 15th floor, 101 College St., Toronto, Ontario, M5G 1L7, Canada

Philip J. Medeiros

Affiliation Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto Medical Discovery Tower, 15th floor, 101 College St., Toronto, Ontario, M5G 1L7, Canada

Wei Xu

Affiliations Department of Biostatistics, University Health Network, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada, Dalla Lana School of Public Health, University of Toronto, 155 College Street, 6th floor, Toronto, Ontario, M5T 3M7, Canada

Lizhen Xu

Affiliation Dalla Lana School of Public Health, University of Toronto, 155 College Street, 6th floor, Toronto, Ontario, M5T 3M7, Canada

Brian C. Wilson

Affiliation Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto Medical Discovery Tower, 15th floor, 101 College St., Toronto, Ontario, M5G 1L7, Canada

Cheryl Rosen

Affiliation Dermatology, Toronto Western Hospital, University Health Network, 399 Bathurst St., Toronto, Ontario, M5T 2S8, Canada

Ron Linden

Affiliation The Judy Dan Treatment and Research Center, 555 Finch Avenue West, Toronto, Ontario, M2R 1N5, Canada

Competing Interests

RSD, BCW and their institution have a pending patent related to this work (“Device and method for fluorescence-based imaging and monitoring” USPTO WO 2009140757 A1), which is being commercialized. RSD an independent investigator with a Scientist appointment at the Princess Margaret Cancer Centre, University Health Network, where he has been the principal investigator on this project. He is also is founder and a shareholder of a spin-off company commercializing the technology. He has Board membership and receives separate compensation as Chief Scientific Officer of the company. LT is a part time employee of the University Health Network (clinical associate); she also receives separate compensation as the clinical trials manager for the company. RSD and LT’s roles in this project were not on behalf of the company but rather in the context of their academic appointments/affiliations. No other authors are associated with or receive compensation or own shares of the company. The authors confirm that the above stated competing interests do not alter the authors’ adherence to all PLOS ONE policies on sharing data and materials. The authors confirm that there are no restrictions on sharing of data and/or materials presented in this work.

Author Contributions

Conceived and designed the experiments: RL CR LLT RSD. Performed the experiments: RL LLT DS YCW JO KB RSD. Analyzed the data: LLT IK YCW WX LX JS RSD. Contributed reagents/materials/analysis tools: YCW RL WX LX RSD. Wrote the paper: IK YCW PM WX LX BCW RSD. Clinical trial management: KB LLT RSD. Technology design: RSD BCW. Regulatory approvals: LLT RSD.