About the Authors

Joanna Lee

Affiliation Structural Bioinformatics and Computational Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom

Veronique Daniels

Affiliation UCB Pharma S.A., Chemin du Foriest, B-1420 Braine-l’Alleud, Belgium

Zara A. Sands

Affiliation UCB Pharma S.A., Chemin du Foriest, B-1420 Braine-l’Alleud, Belgium

Florence Lebon

Affiliation UCB Pharma S.A., Chemin du Foriest, B-1420 Braine-l’Alleud, Belgium

Jiye Shi

Affiliation UCB Pharma S.A., Chemin du Foriest, B-1420 Braine-l’Alleud, Belgium

Philip C. Biggin

philip.biggin@bioch.ox.ac.uk

Affiliation Structural Bioinformatics and Computational Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom

Competing Interests

Joanna Lee is a BBSRC-funded student in receipt of additional financial support from UCB BioPharma SPRL. Zara Sands, Florence Lebon and Jiye Shi are all employees of UCB BioPharma SPRL. During the course of the research reported herein, Veronique Daniels was an employee of UCB BioPharma SPRL and her research was supported by a grant from the Walloon Region (Belgium) – DGO6 (Convention 6536). There are no patents or products in development or marketed products to declare that arise from this work. This does not alter the authors’ adherence to PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JL VD ZAS FL PCB. Performed the experiments: JL VD. Analyzed the data: JL VD ZAS FL JS PCB. Contributed reagents/materials/analysis tools: JL VD ZAS FL JS PCB. Wrote the paper: JL VD ZAS FL JS PCB.