About the Authors

Julia Peterson

Affiliation Department of Neurology, University of California San Francisco, San Francisco, CA, United States of America

Magnus Gisslen

Affiliation Department of Infectious Diseases, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

Henrik Zetterberg

Affiliation Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden, Institute of Neurology, Queen Square, London, United Kingdom

Dietmar Fuchs

Affiliation Division of Biological Chemistry, Innsbruck Medical University, Innsbruck, Austria

Barbara L. Shacklett

Affiliation Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, CA, United States of America

Lars Hagberg

Affiliation Department of Infectious Diseases, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

Constantin T. Yiannoutsos

Affiliation Department of Biostatistics, Indiana University, R.M. Fairbanks School of Public Health, Indianapolis, IN, United States of America

Serena S. Spudich

Affiliation Department of Neurology, Yale University School of Medicine, New Haven, CT, United States of America

Richard W. Price

rwprice@sfgh.ucsf.edu

Affiliation Department of Neurology, University of California San Francisco, San Francisco, CA, United States of America

Competing Interests

The authors have no competing interests that could be construed as influencing the contents of this paper. However the authors list the following general potential conflicts of interest: RWP has been a consultant to Merck and Co and has received an honorarium and travel support from Abbott Laboratories/AbbVie for meeting presentations. MG has received research grants from Abbott, Baxter, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, Merck, Pfizer, Roche and Tibotec, and he has received honoraria as a speaker and/or advisor from Abbott/Abbvie, Bioinvent, Boehringer-Ingelheim, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, Janssen-Cilag, Merck, Pfizer, Roche and Tibotec/Janssen. SS has received an honorarium and travel support from AbbVie, Inc. for a meeting presentation. HZ reports no conflicts. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MG HZ RWP. Performed the experiments: JP MG HZ DF BLS LH SSS RWP. Analyzed the data: JP MG HZ CTY RWP. Contributed reagents/materials/analysis tools: HZ DF. Wrote the paper: JP MG HZ BLS SSS RWP.