About the Authors

Alicja. J. Copik

Current address: Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, 6900 Lake Nona Blvd., Orlando, FL 32827, United States of America

Affiliation Biochemical Pharmacology, Inflammation Discovery, Roche Palo Alto LLC, 3401 Hillview Drive, Palo Alto, CA 94304, United States of America

Aleksander Baldys

Current address: Simens 1275 York Ave, New York, NY 10065, United States of America

Affiliation Nephrology Division, Department of Medicine, Medical University of South Carolina, and Medical and Research Services, Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina 29425, United States of America

Khanh Nguyen

Current address: Anshin BioSolutions, 5201 Great America Pkwy, Suite 320, Santa Clara, CA 9505, United States of America

Affiliation Discovery Technologies, Roche Palo Alto LLC, 3401 Hillview Drive, Palo Alto, CA 94304, United States of America

Sunil Sahdeo

Current address: Janssen Pharmaceuticals, 3210 Merryfield Row, San Diego, CA 92121, United States of America

Affiliation Biochemical Pharmacology, Inflammation Discovery, Roche Palo Alto LLC, 3401 Hillview Drive, Palo Alto, CA 94304, United States of America

Hoangdung Ho

Current address: Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States of America

Affiliation Discovery Technologies, Roche Palo Alto LLC, 3401 Hillview Drive, Palo Alto, CA 94304, United States of America

Alan Kosaka

Affiliation Discovery Technologies, Roche Palo Alto LLC, 3401 Hillview Drive, Palo Alto, CA 94304, United States of America

Paul J. Dietrich

Affiliation Discovery Technologies, Roche Palo Alto LLC, 3401 Hillview Drive, Palo Alto, CA 94304, United States of America

Bill Fitch

Current address: Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, United States of America

Affiliation Discovery Technologies, Roche Palo Alto LLC, 3401 Hillview Drive, Palo Alto, CA 94304, United States of America

John R. Raymond

Affiliation Nephrology Division, Department of Medicine, Medical University of South Carolina, and Medical and Research Services, Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina 29425, United States of America

Anthony P. D. W. Ford

Current address: Afferent Pharmaceuticals, 2755 Campus Dr. Suite 100, San Mateo, CA 94403, United States of America

Affiliation Biochemical Pharmacology, Inflammation Discovery, Roche Palo Alto LLC, 3401 Hillview Drive, Palo Alto, CA 94304, United States of America

Donald Button

Current address: Acorda Therapeutics, Inc.15 Skyline Drive, Hawthorne, NY 10532, United States of America

Affiliation Biochemical Pharmacology, Inflammation Discovery, Roche Palo Alto LLC, 3401 Hillview Drive, Palo Alto, CA 94304, United States of America

Marcos E. Milla

mmilla22@its.jnj.com

Affiliation Biochemical Pharmacology, Inflammation Discovery, Roche Palo Alto LLC, 3401 Hillview Drive, Palo Alto, CA 94304, United States of America

Competing Interests

With regard to competing interests, please note the affiliation of authors AJC, KN, SS, HH, AK, PJD, BF, APDWF, DB and MEM to Roche Palo Alto LLC. Again, this does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AJC AB APDWF DB MEM. Performed the experiments: AJC AB KN SS HH. Analyzed the data: AJC AB APDWF DB MEM. Contributed reagents/materials/analysis tools: AJC AB KN SS HH AK PJD BF. Wrote the paper: AJC AB KN SS HH AK PJD BF JRR APDWF DB MEM.