About the Authors

Andrew Osborne

Affiliation School of Pharmacy, University of East Anglia, Norwich, United Kingdom

Amal Aldarwesh

Affiliation School of Pharmacy, University of East Anglia, Norwich, United Kingdom

Jeremy D. Rhodes

Affiliation School of Biological Sciences, University of East Anglia, Norwich, United Kingdom

David C. Broadway

Affiliations School of Pharmacy, University of East Anglia, Norwich, United Kingdom, School of Biological Sciences, University of East Anglia, Norwich, United Kingdom, Department of Ophthalmology, Norfolk and Norwich University Hospital, Norwich, United Kingdom

Claire Everitt

Affiliation Pfizer Ltd, Design Centre of Excellence, Granta Park, Great Abington, Cambridge, United Kingdom

Julie Sanderson

j.sanderson@uea.ac.uk

Affiliation School of Pharmacy, University of East Anglia, Norwich, United Kingdom

Competing Interests

CE is an employee of Pfizer Ltd. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AO JDR DCB JS. Performed the experiments: AO AA. Analyzed the data: AO JS AA JDR CE. Contributed reagents/materials/analysis tools: JDR. Wrote the paper: AO JS CE.