Evolution of BCR/ABL Gene Mutation in CML Is Time Dependent and Dependent on the Pressure Exerted by Tyrosine Kinase Inhibitor

Shantashri Vaidya; Babu Rao Vundinti; Chandrakala Shanmukhaiah; Prantar Chakrabarti; Kanjaksha Ghosh

doi:10.1371/journal.pone.0114828

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Open Access

Peer-reviewed

Research Article

Evolution of BCR/ABL Gene Mutation in CML Is Time Dependent and Dependent on the Pressure Exerted by Tyrosine Kinase Inhibitor

Shantashri Vaidya,

Affiliation Department of Cytogenetics, National Institute of Immunohaematology, 13th Floor, New Multistoried Building, KEM Hospital Campus, Parel, Mumbai, 400012, India
⨯
Babu Rao Vundinti,

Affiliation Department of Cytogenetics, National Institute of Immunohaematology, 13th Floor, New Multistoried Building, KEM Hospital Campus, Parel, Mumbai, 400012, India
⨯
Chandrakala Shanmukhaiah,

Affiliation Department of Haematology, 10th Floor, New Multistoried Building, KEM Hospital, Parel, Mumbai, 400012, India
⨯
Prantar Chakrabarti,

Affiliation Institute of Haematology and Transfusion Medicine, Kolkata, West Bengal, 700073, India
⨯
Kanjaksha Ghosh

* E-mail: kanjakshaghosh@hotmail.com

Affiliation Department of Cytogenetics, National Institute of Immunohaematology, 13th Floor, New Multistoried Building, KEM Hospital Campus, Parel, Mumbai, 400012, India
⨯

Evolution of BCR/ABL Gene Mutation in CML Is Time Dependent and Dependent on the Pressure Exerted by Tyrosine Kinase Inhibitor

Shantashri Vaidya,
Babu Rao Vundinti,
Chandrakala Shanmukhaiah,
Prantar Chakrabarti,
Kanjaksha Ghosh

Published: January 28, 2015
https://doi.org/10.1371/journal.pone.0114828

About the Authors

Shantashri Vaidya

Affiliation Department of Cytogenetics, National Institute of Immunohaematology, 13th Floor, New Multistoried Building, KEM Hospital Campus, Parel, Mumbai, 400012, India

Babu Rao Vundinti

Affiliation Department of Cytogenetics, National Institute of Immunohaematology, 13th Floor, New Multistoried Building, KEM Hospital Campus, Parel, Mumbai, 400012, India

Chandrakala Shanmukhaiah

Affiliation Department of Haematology, 10th Floor, New Multistoried Building, KEM Hospital, Parel, Mumbai, 400012, India

Prantar Chakrabarti

Affiliation Institute of Haematology and Transfusion Medicine, Kolkata, West Bengal, 700073, India

Kanjaksha Ghosh

* E-mail: kanjakshaghosh@hotmail.com

Affiliation Department of Cytogenetics, National Institute of Immunohaematology, 13th Floor, New Multistoried Building, KEM Hospital Campus, Parel, Mumbai, 400012, India

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KG BRV. Performed the experiments: SV. Analyzed the data: SV BRV CS PC KG. Contributed reagents/materials/analysis tools: SV BRV KG. Wrote the paper: SV BRV KG. Clinical evaluation of patients: CS PC.

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Point mutation
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Insertion mutation
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Deletion mutation
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Mutation detection
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Cytogenetics
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Hematology
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Stem cell therapy
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Mutation
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