About the Authors

Tatsuya Isomura

tatsuya_isomura@jp-css.com

Affiliations CLINICAL STUDY SUPPORT, Inc., Nagoya, Aichi, Japan, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan

Takeshi Kono

Affiliation Department of Dermatology, Nippon Medical School Chiba-Hokusoh Hospital, Chiba, Japan

Ian Hindmarch

Affiliation University of Surrey, Guildford, Surrey, United Kingdom

Norimasa Kikuchi

Affiliation CLINICAL STUDY SUPPORT, Inc., Nagoya, Aichi, Japan

Aya Murakami

Affiliation CLINICAL STUDY SUPPORT, Inc., Nagoya, Aichi, Japan

Kyoko Inuzuka

Affiliation CLINICAL STUDY SUPPORT, Inc., Nagoya, Aichi, Japan

Seiji Kawana

Affiliation Department of Dermatology, Nippon Medical School, Tokyo, Japan

Competing Interests

TI and NK are founders of CLINICAL STUDY SUPPORT, Inc. AM and KI are employees of CLINICAL STUDY SUPPORT, Inc. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TI TK IH NK. Performed the experiments: TI AM KI. Analyzed the data: TI TK IH AM KI. Wrote the paper: TI TK IH NK AM KI SK.