About the Authors

Rossella Russo

rossella.russo@unical.it (RR); mtcorasa@unicz.it (MTC)

Affiliation Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, Rende, Cosenza, Italy

Maria Gilda Valentina Cassiano

Affiliation Department of Health Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, Italy

Antonella Ciociaro

Affiliation Department of Health Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, Italy

Annagrazia Adornetto

Affiliation Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, Rende, Cosenza, Italy

Giuseppe Pasquale Varano

Affiliation Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, Rende, Cosenza, Italy

Carlotta Chiappini

Affiliation Department of Health Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, Italy

Laura Berliocchi

Affiliation Department of Health Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, Italy

Cristina Tassorelli

Affiliation Headache Science Centre, National Neurological Institute “C. Mondino,” and Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy

Giacinto Bagetta

Affiliation Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, Rende, Cosenza, Italy

Maria Tiziana Corasaniti

rossella.russo@unical.it (RR); mtcorasa@unicz.it (MTC)

Affiliation Department of Health Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, Italy

Competing Interests

BEO was kindly provided by CAPUA s.r.l., which had no role in study design, analysis and interpretation of data, in the writing of the manuscript and in the decision to submit the paper for publication, nor did it oblige the authors to any limitation in sharing materials and data. The authors confirm adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RR MTC. Performed the experiments: MGVC AC AA GPV CC. Analyzed the data: RR MTC LB. Contributed reagents/materials/analysis tools: CT GB. Wrote the paper: RR MTC.