The Shigella flexneri Type 3 Secretion System Is Required for Tyrosine Kinase-Dependent Protrusion Resolution, and Vacuole Escape during Bacterial Dissemination

Carole J. Kuehl; Ana-Maria Dragoi; Hervé Agaisse

doi:10.1371/journal.pone.0112738

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Peer-reviewed

Research Article

The Shigella flexneri Type 3 Secretion System Is Required for Tyrosine Kinase-Dependent Protrusion Resolution, and Vacuole Escape during Bacterial Dissemination

Carole J. Kuehl,

Affiliation Department of Microbial Pathogenesis, Yale School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut, United States of America
⨯
Ana-Maria Dragoi,

Affiliation Department of Microbial Pathogenesis, Yale School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut, United States of America
⨯
Hervé Agaisse

* E-mail: herve.agaisse@yale.edu

Affiliation Department of Microbial Pathogenesis, Yale School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut, United States of America
⨯

The Shigella flexneri Type 3 Secretion System Is Required for Tyrosine Kinase-Dependent Protrusion Resolution, and Vacuole Escape during Bacterial Dissemination

Carole J. Kuehl,
Ana-Maria Dragoi,
Hervé Agaisse

Published: November 18, 2014
https://doi.org/10.1371/journal.pone.0112738

About the Authors

Carole J. Kuehl

Affiliation Department of Microbial Pathogenesis, Yale School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut, United States of America

Ana-Maria Dragoi

Affiliation Department of Microbial Pathogenesis, Yale School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut, United States of America

Hervé Agaisse

* E-mail: herve.agaisse@yale.edu

Affiliation Department of Microbial Pathogenesis, Yale School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CJK AMD HA. Performed the experiments: CJK AMD. Analyzed the data: CJK AMD HA. Wrote the paper: CJK HA.

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Vacuoles
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Shigella flexneri
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Cell membranes
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Pathogen motility
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Cytosol
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Cell motility
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Tyrosine kinases
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Bacterial pathogens
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