About the Authors

Daisuke Sunaga

Affiliation Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

Masaya Tanno

Affiliation Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

Atsushi Kuno

Affiliation Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

Satoko Ishikawa

Affiliation Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

Makoto Ogasawara

Affiliation Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

Toshiyuki Yano

Affiliation Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

Takayuki Miki

Affiliation Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

Tetsuji Miura

miura@sapmed.ac.jp

Affiliation Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

Competing Interests

Tetsuji Miura received research grant support from Chugai Pharmaceutical Co. Ltd. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: T. Miura T. Miki. Performed the experiments: DS AK SI MO. Analyzed the data: MO TY. Wrote the paper: DS MT T. Miura.