About the Authors

Naoto Tsuda

naoto.tsuda@mochida.co.jp

Affiliations Discovery Research, Mochida Pharmaceutical Company Limited, Shizuoka, Japan, Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

Shin Kumadaki

Affiliation Discovery Research, Mochida Pharmaceutical Company Limited, Shizuoka, Japan

Chika Higashi

Affiliation Discovery Research, Mochida Pharmaceutical Company Limited, Shizuoka, Japan

Makoto Ozawa

Affiliation Discovery Research, Mochida Pharmaceutical Company Limited, Shizuoka, Japan

Mikihiko Shinozaki

Affiliation Discovery Research, Mochida Pharmaceutical Company Limited, Shizuoka, Japan

Yutaka Kato

Affiliation Discovery Research, Mochida Pharmaceutical Company Limited, Shizuoka, Japan

Koutarou Hoshida

Affiliation Discovery Research, Mochida Pharmaceutical Company Limited, Shizuoka, Japan

Satomi Kikuchi

Affiliation Discovery Research, Mochida Pharmaceutical Company Limited, Shizuoka, Japan

Yoshihisa Nakano

Affiliation Discovery Research, Mochida Pharmaceutical Company Limited, Shizuoka, Japan

Yoshihiro Ogawa

Affiliation Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

Shoji Furusako

Affiliation Discovery Research, Mochida Pharmaceutical Company Limited, Shizuoka, Japan

Competing Interests

Mochida Pharmaceutical provided all funds for this work. NT, SK, CH, MO, MS, YK, KH, SK, YN, and SF are current employees of Mochida Pharmaceutical and may own stock or hold stock options in Mochida Pharmaceutical. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NT SK CH MO MS YK KH SK YN YO SF. Performed the experiments: NT SK CH MO MS YK KH SK YN. Analyzed the data: NT SK CH MO KH SK YN. Contributed reagents/materials/analysis tools: NT SK CH MS YK SK YN. Contributed to the writing of the manuscript: NT YK.