About the Authors

Ingo Flamme

ingo.flamme@bayer.com

Affiliation Cardiology/Hematology, Acute Care Research, Global Drug Discovery, Bayer Pharma AG, Wuppertal, Germany

Felix Oehme

Affiliation Biotech Development, Global Biologics, Bayer Pharma AG, Wuppertal, Germany

Peter Ellinghaus

Affiliation Clinical Science, Global Biomarkers, Bayer Pharma AG, Wuppertal, Germany

Mario Jeske

Affiliation Global Chemical Product Development, Bayer Pharma AG, Wuppertal, Germany

Jörg Keldenich

Affiliation Drug Metabolism and Pharmacokinetics, Global Early Development, Bayer Pharma AG, Wuppertal, Germany

Uwe Thuss

Affiliation Drug Metabolism and Pharmacokinetics, Global Early Development, Bayer Pharma AG, Wuppertal, Germany

Competing Interests

Dr. Flamme has read the journal’s policy and the authors of this manuscript have the following competing interests: All the authors are employees of Bayer Pharma AG, the funding organization for this study. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: IF FO PE MJ JK UT. Performed the experiments: IF FO PE JK UT. Analyzed the data: IF FO PE MJ JK UT. Contributed reagents/materials/analysis tools: FO MJ. Contributed to the writing of the manuscript: IF FO PE MJ JK UT.