About the Authors

Rie Yamamoto

Affiliation Tsukuba Research Center, Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan

Youhei Okada

Affiliation Tsukuba Research Center, Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan

Jun Hirose

Affiliation Tsukuba Research Center, Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan

Tadatsura Koshika

Affiliation Tsukuba Research Center, Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan

Yuka Kawato

Affiliation Tsukuba Research Center, Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan

Masashi Maeda

Affiliation Tsukuba Research Center, Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan

Rika Saito

Affiliation Kashima R&D Center, Drug Discovery Research, Astellas Pharma Inc., Osaka, Japan

Kazuyuki Hattori

Affiliation Tsukuba Research Center, Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan

Hironori Harada

Affiliation Tsukuba Research Center, Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan

Yasuhisa Nagasaka

Affiliation Tsukuba Research Center, Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan

Tatsuaki Morokata

tatsuaki.morokata@astellas.com

Affiliation Tsukuba Research Center, Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan

Competing Interests

The authors have read the journal's policy, and they have the following competing interests: All authors are employed by Astellas Pharma Inc. HH, KH and TM are listed as inventors on a patent application (publication number WO2007/116866) covering the compound described in this manuscript. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RY TM. Performed the experiments: RY YO JH TK YK MM RS YN TM. Analyzed the data: RY YO RS YN. Contributed reagents/materials/analysis tools: KH HH. Wrote the paper: RY TM.